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النتائج لكل صفحة: 10

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Subject : 3. good health

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Academic Journal

A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

Authors : Jin Lee; Xiaoxi Chen; Yuming Wang

Subjects: Methylenetetrahydrofolate Dehydrogenase (NADP); Mice, Knockout; 0301 basic medicine

Source: Biochemical and Biophysical Research Communications. 584:7-14

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Academic Journal

P90 ribosomal S6 kinase confers cancer cell survival by mediating checkpoint kinase 1 degradation in response to glucose stress

Authors : Ying Ma; Danrui Cui; Linchen Wang

Subjects: 0301 basic medicine; Cell Survival; Pteridines

Source: Cancer Sci

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Academic Journal

Enhanced Efficacy of Combined Therapy with Checkpoint Kinase 1 Inhibitor and Rucaparib via Regulation of Rad51 Expression in BRCA Wild-Type Epithelial Ovarian Cancer Cells

Authors : Yong Beom Kim; Wook Ha Park; Hye Yon Cho

Subjects: BRCA2 Protein; Ovarian Neoplasms; Indoles

Source: Cancer Res Treat

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Academic Journal

Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas

Authors : Zhen Zeng; Hung Long Ngo; Martina Proctor

Subjects: treatment resistance; replication stress; Biochemistry and cell biology

Source: Pigment Cell & Melanoma Research. 37:45-50

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Academic Journal

A Tiered Female Ovarian Toxicity Screening Identifies Toxic Effects of Checkpoint Kinase 1 Inhibitors on Murine Growing Follicles

Authors : Jingshan Xu; Jie Zhu; Shuo Xiao

Subjects: 0301 basic medicine; Mice; 03 medical and health sciences

Source: Toxicological Sciences. 177:405-419

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Academic Journal

Discovery and in silico evaluation of aminoarylbenzosuberene molecules as novel checkpoint kinase 1 inhibitor determinants

Authors : Jatin Sharma; Vijay Kumar Bhardwaj; Rahul Singh

Subjects: Molecular Docking Simulation; 0301 basic medicine; 03 medical and health sciences

Source: Genomics. 113:707-715

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Academic Journal

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Authors : Kaylee M. Keller; Thomas F. Eleveld; Linda Schild ...

Subjects: 0301 basic medicine; Cancer Research; replication stress

Source: Front OncolFrontiers in Oncology, Vol 12 (2022)Keller, K M, Eleveld, T F, Schild, L, van den Handel, K, van den Boogaard, M, Amo-Addae, V, Eising, S, Ober, K, Koopmans, B, Looijenga, L,

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Academic Journal

Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway

Authors : Yi Fan; Yiwei Cheng; Yafei Li

Subjects: 0301 basic medicine; Mice, Inbred ICR; Proteome

Source: Circulation. 141:1554-1569

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Academic Journal

Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse

Authors : Guillermo Urrutia; Ann Salmonson; Jorge Toro-Zapata ...

Subjects: DNA Replication; 0301 basic medicine; [SDV]Life Sciences [q-bio]

Source: Molecular Cancer ResearchMolecular Cancer Research, American Association for Cancer Research, 2020, 18 (3), pp.448-462. ⟨10.1158/1541-7786.MCR-19-0490⟩

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Academic Journal

Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension

Authors : Bourgeois, Alice; Bonnet, Sébastien; Breuils-Bonnet, Sandra ...

Subjects: Male; Pulmonary Arterial Hypertension; [SDV]Life Sciences [q-bio]

Source: Arteriosclerosis, Thrombosis, and Vascular BiologyArteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2019, 39 (8), pp.1667-1681. ⟨10.1161/ATVBAHA.119.312537⟩

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