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Subject : 0302 clinical medicine

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RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

Authors : Laila A. Bishara; Samah W. Awwad; Feras E. Machour

Subjects: AcademicSubjects/SCI00010; RNA Stability; Antineoplastic Agents

Source: Nucleic Acids ResearchNucleic Acid Research

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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition

Authors : Talysa Viera; Megha Khandelwal; Julio C. Morales

Subjects: 0301 basic medicine; Genome instability; DNA Replication

Source: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)Scientific Reports

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Medical Management of newly diagnosed breast cancer in a BRCA1/2 mutation carrier

Authors : Neelam V. Desai; Nadine Tung

Subjects: Oncology; medicine.medical_specialty; endocrine system diseases

Source: The Breast Journal. 26:1506-1512

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The efficacy and safety of the addition of poly ADP-ribose polymerase (PARP) inhibitors to therapy for ovarian cancer: a systematic review and meta-analysis

Authors : Yingzhu Yang; Jiahang Mo; Nannan Du

Subjects: 0301 basic medicine; Oncology; medicine.medical_specialty

Source: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-11 (2020)World Journal of Surgical Oncology

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PARP inhibitor resistance: the underlying mechanisms and clinical implications

Authors : Quan Cheng; Nayiyuan Wu; He Li

Subjects: 0301 basic medicine; Cancer Research; Synthetic lethality

Source: Molecular Cancer, Vol 19, Iss 1, Pp 1-16 (2020)Molecular Cancer

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Systems approach to rational combination therapy: PARP inhibitors

Authors : Gordon B. Mills; Chaoyang Sun; Xi Li

Subjects: G2 Phase; MAPK/ERK pathway; DNA Repair

Source: Biochem Soc Trans

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Molecular and clinical characterization of PARP9 in gliomas: A potential immunotherapeutic target

Authors : Dongdong Xiao; Junjun Li; Hao Xu

Subjects: 0301 basic medicine; Adult; Male

Source: CNS Neuroscience & Therapeutics

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Molecular natural history of breast cancer: Leveraging transcriptomics to predict breast cancer progression and aggressiveness

Authors : Jonatan Kallus; Rebecka Jörnsten; Jens Nielsen

Subjects: 0301 basic medicine; Oncology; Cancer Research

Source: Cancer MedicineCook, D J, Kallus, J, Jörnsten, R & Nielsen, J 2020, ' Molecular natural history of breast cancer: Leveraging transcriptomics to predict breast cancer progression and

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Gamma ray-induced in vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pretreatment

Authors : Utpal Ghosh; Priyanka Chowdhury; Debapriya De

Subjects: MAPK/ERK pathway; medicine.medical_treatment; p38 mitogen-activated protein kinases

Source: International Journal of Radiation Biology. 96:651-660

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PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells

Authors : Jan Haug Anonsen; Venkata Satheesh Somisetty; Denis M. Grant

Subjects: mono-ADP-ribosylation; Estrogen receptor; Breast Neoplasms

Source: CellsVolume 10Issue 3Cells, Vol 10, Iss 623, p 623 (2021)

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