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Gene Therapy for Neurofibromatosis Type 2 (NF2) with ST002

• Authors : NING LI, Vice president of Cancer Hospital Chinese Academy of Medical Sciences

• Source: An Open- Label, Single-arm, Dose-escalation Pilot Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ST002 in the Treatment of Patients with NF2

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Testing VS-6063 (Defactinib) as a Potential Targeted Treatment in Cancers With NF2 Genetic Changes (MATCH-Subprotocol U)

• Source: MATCH Treatment Subprotocol U: VS-6063 (Defactinib) in Patients With Tumors With NF2 Loss

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Phase II Study of FCN-159 in NF2 Nerve Sheath Tumors

• Source: An Open, Single-Arm Phase II Study Evaluating the Efficacy and Safety of FCN-159 in Selected NF2-associated Nerve Sheath Tumors

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors Enriched for Tumors With NF2 or mNF2 Gene Mutations

• Source: Phase 1, Multi-Center, Open-Label Study of VT3989 in Patients With Refractory Locally Advanced or Metastatic Solid Tumors Enriched for Tumors Harboring Mutations of the Neurofibromatosis Type 2 Gene

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89Zr-Bevacizumab PET/CT Imaging in NF2 Patients

• Authors : Hans Gelderblom, Prof. A.J. Gelderblom, MD, PhD, Head of Medical Oncology, Principal Investigator

• Source: 89Zr-Bevacizumab PET/CT Imaging of Vestibular Schwannomas for the Prediction of Bevacizumab Treatment Effect in Patients With Symptomatic Neurofibromatosis Type 2

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Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas (POPLAR-NF2)

• Source: A Two-staged, Phase 2/3, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of REC-2282 in Participants With Progressive NF2 Mutated Meningiomas

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Doxycycline in Cutaneous Schwannoma (NF2)

• Authors : D. Bradley Welling, MD, PhD, Professor Harvard Department of Otolaryngology-Head and Neck Surgery

• Source: Doxycycline Injection of Cutaneous Schwannoma in Neurofibromatosis Type 2Ren Y, Chari DA, Vasilijic S, Welling DB, Stankovic KM. New developments in neurofibromatosis type 2 and vestibular

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AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas

• Authors : AstraZeneca; United States Department of Defense; Scott R. Plotkin, MD, PhD, Principal Investigator

• Source: A Single Arm Phase 2 Study of the Dual mTORC1/mTORC2 Inhibitor AZD2014 Provided on an Intermittent Schedule for Neurofibromatosis 2 Patients With Progressive or Symptomatic Meningiomas

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Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors (Icotinib)

• Authors : Betta Pharmaceuticals Co., Ltd.; Li Peng, principal investigator

• Source: Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors

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A Single Center Pilot Study to Assess the Intra-observer Reliability of Measuring Muscle Strength Using a Hand Held Dynamometer in Children and Adults With Neurofibromatosis Type 1 (NF1) and Type 2 (NF2)

• Source: A Single Center Pilot Study to Assess the Intra-observer Reliability of Measuring Muscle Strength Using a Hand Held Dynamometer in Children and Adults With Neurofibromatosis Type 1 (NF1) and Type 2

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