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Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma

• Source: An Open-Label Non-Randomized, Multi-Center Phase-2 Study of Convection-Enhanced Delivery (

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Topotecan Using Convection-Enhanced Delivery (CED) in High Grade Glioma

• Authors : Infuseon Therapeutics, Inc.; Michael Vogelbaum, MD, PhD, Principal Investigator

• Source: A Pilot Trial of Intraparenchymally-Administered Topotecan Using Convection-Enhanced Delivery (

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Chronic CED of TPT for Recurrent Malignant Glioma (TPT CED rHGG)

• Authors : Jeffrey N. Bruce, Professor of Neurological Surgery

• Source: Chronic Convection Enhanced Delivery of Topotecan for Recurrent Malignant GliomaSonabend AM, Stuart

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D2C7 for Adult Patients With Recurrent Malignant Glioma

• Authors : Darell Bigner, Edwin L. Jones, Jr. and Lucille Finch Jones Cancer Research Professor

• Source: Phase I Single-Center, Dose Escalation Study of D2C7-IT Administered Intratumorally Via Convection-Enhanced

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CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

• Authors : Midatech Pharma US Inc.; Luca Szalontay, Herbert and Florence Irving Associate Professor of Pediatric Neuro-Oncology

• Source: A Phase I Study Examining the Feasibility of Intermittent Convection-Enhanced Delivery (

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Chronic Convection Enhanced Delivery of Topotecan

• Authors : National Cancer Institute (NCI); Jeffrey N. Bruce, Edgar M. Housepian Professor of Neurological Surgery Research at, Dept of Neurological Surgery

• Source: Chronic Convection Enhanced Delivery of Topotecan for Recurrent High Grade GliomasSpinazzi EF,

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AMT-260 Gene Therapy Study in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (GenTLE)

• Source: A Multi-center, Phase 1/2a, First-in-human (FIH) Study Investigating the Safety, Tolerability, and Efficacy of AMT-260 in Adults with Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE)

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D2C7-IT + 2141-V11 Combination Post-resection in rGBM

• Authors : Rockefeller University; Darell Bigner, Sponsor-Investigator

• Source: Clinical Trial of D2C7-IT + 2141-V11 Combination Immunotherapy Administered Via Convection Enhanced

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AAV2-GDNF for Advanced Parkinson s Disease

• Source: A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (

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Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 (PuMP)

• Authors : Mustafa Khasraw, MBChB, MD, FRCP, FRACP, Professor of Neurosurgery

• Source: The PuMP Trial: "A Multistage Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 in Patients With Recurrent High-Grade Glioma"

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