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A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid Tumors

• Source: A Phase I Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid

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A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients With Advanced Cancer

• Source: A Phase 1b Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients With Advanced Cancer

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Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress

• Authors : Desmarais, Joelle; Unger, Christian; Damjanov, Ivan

Subjects: Induced pluripotent stem cells; Integration-free reprogramming; Checkpoint kinase 1

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Identification of Prognostic Biomarkers for Stage III Non-Small Cell Lung Carcinoma in Female Nonsmokers Using Machine Learning

• Authors : Zheng, Huili; Zhang, Qimin; Gong, Yiru

Subjects: Quantitative Biology - Genomics; Computer Science - Artificial Intelligence; Statistics - Machine Learning

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Study of the CHK1 Inhibitor BBI-355, an EcDNA-directed Therapy (ecDTx), in Subjects with Tumors with Oncogene Amplifications (POTENTIATE)

• Source: An Open-Label, Multicenter, First-in-Human, Dose-Escalation and Dose-Expansion, Phase 1/2 Study of BBI-355 and BBI-355 in Combination with Select Targeted Therapies in

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I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers (MATRIX)

• Authors : National Cancer Institute, France; Merck KGaA, Darmstadt, Germany

• Source: A Phase I/II Study Evaluating M1774, an ATR Inhibitor, in Combination With Fulvestrant in Hormone Receptor-positive and HER2-negative, Advanced Breast Cancers, Resistant to CDK4/6 Inhibitor Plus

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Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors

• Authors : National Cancer Institute (NCI)

• Source: A Phase 1 Study of LY2606368 (Prexasertib Mesylate Monohydrate) a CHK1/2 Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS

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A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer

• Source: A Phase 1/2 Trial of SRA737 (a Chk1 Inhibitor) Administered Orally in Subjects With Advanced CancerJin T, Xu L, Wang P, Hu X, Zhang R, Wu Z, Du W, Kan W, Li K,

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A Study of LY2606368 (Prexasertib) in Patients With Solid Tumors With Replicative Stress or Homologous Repair Deficiency

• Authors : Geoffrey Shapiro, MD, PhD, Geoffrey Shapiro M.D., PhD

• Source: A Phase II Study of the CHK1 Inhibitor LY2606368 in Patients With Advanced Solid Tumors Exhibiting Replicative Stress or Homologous Recombination Repair Deficiency

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A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) in BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, High Grade Serous Ovarian Cancer, and Metastatic Castrate-Resistant Prostate Cancer

• Authors : Jung-Min Lee, M.D., Principal Investigator

• Source: A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) In BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, and High Grade Serous Ovarian Cancer

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