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Academic Journal

PacBio sequencing detects genome-wide ultra-low-frequency substitution mutations resulting from exposure to chemical mutagens.

Authors : Revollo JR; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.; Miranda JA

Subjects: Mutation*; Alkylating Agents/Alkylating Agents/Alkylating Agents/*toxicity ; Escherichia coli/Escherichia coli/Escherichia coli/*genetics

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2021 Oct; Vol. 62 (8), pp. 438-445. Date of Electronic Publication: 2021 Sep 02.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Methodologies for detecting environmentally induced DNA damage and repair.

Authors : Li W; Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.; Sancar A

Subjects: DNA Damage/DNA Damage/DNA Damage/*drug effects ; DNA Damage/DNA Damage/DNA Damage/*genetics ; DNA Repair/DNA Repair/DNA Repair/*drug effects

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Aug; Vol. 61 (7), pp. 664-679. Date of Electronic Publication: 2020 Feb 29.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

A Return to the Origin of the EMGS: Rejuvenating the Quest for Human Germ Cell Mutagens and Determining the Risk to Future Generations.

Authors : Marchetti F; Environmental Health Science Research Bureau, Health Canada, Ottawa, Ontario, Canada.; Douglas GR

Subjects: Environmental Exposure/Environmental Exposure/Environmental Exposure/*adverse effects ; Germ Cells/Germ Cells/Germ Cells/*drug effects ; Mutagens/Mutagens/Mutagens/*toxicity

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Jan; Vol. 61 (1), pp. 42-54. Date of Electronic Publication: 2019 Oct 10.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk.

Authors : Salk JJ; Department of Medicine, Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.; TwinStrand Biosciences, Seattle, Washington.

Subjects: High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/*methods ; Mutagenesis/Mutagenesis/Mutagenesis/*drug effects ; Mutagens/Mutagens/Mutagens/*toxicity

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Jan; Vol. 61 (1), pp. 135-151. Date of Electronic Publication: 2019 Nov 11.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk.

Authors : Harris KL; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas.; Myers MB

Subjects: Mutation*/Mutation*/Mutation*/drug effects; Carcinogenesis/Carcinogenesis/Carcinogenesis/*genetics ; Neoplasms/Neoplasms/Neoplasms/*genetics

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Jan; Vol. 61 (1), pp. 152-175. Date of Electronic Publication: 2019 Oct 06.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Mutation as a Toxicological Endpoint for Regulatory Decision-Making.

Authors : Heflich RH; U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas.; Johnson GE

Subjects: Mutagenicity Tests/Mutagenicity Tests/Mutagenicity Tests/*methods ; Mutagens/Mutagens/Mutagens/*toxicity; Animals

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2020 Jan; Vol. 61 (1), pp. 34-41. Date of Electronic Publication: 2019 Oct 23.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Authors : Saini N; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Durham, North Carolina.; Gordenin DA

Subjects: DNA Damage/DNA Damage/DNA Damage/*genetics ; DNA Repair/DNA Repair/DNA Repair/*genetics ; Genomic Instability/Genomic Instability/Genomic Instability/*genetics

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2018 Oct; Vol. 59 (8), pp. 672-686. Date of Electronic Publication: 2018 Aug 27.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Development of a high-throughput genotoxicity assay using Umu test strains expressing human cytochrome P450s and NADPH-P450 reductase and bacterial O-acetyltransferase.

Authors : Hori H; Safety Science Institute, Suntory MONOZUKURI Expert Limited, Seika-cho, Soraku-gun, Kyoto, Japan.; Hirata D

Subjects: Acetyltransferases/Acetyltransferases/Acetyltransferases/*genetics ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*genetics ; High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/*methods

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2017 May; Vol. 58 (4), pp. 209-216. Date of Electronic Publication: 2017 Apr 24.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.

Authors : Revollo JR; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas.; Crabtree NM

Subjects: Mutation*; 9,10-Dimethyl-1,2-benzanthracene/9,10-Dimethyl-1,2-benzanthracene/9,10-Dimethyl-1,2-benzanthracene/*toxicity ; DNA Mutational Analysis/DNA Mutational Analysis/DNA Mutational Analysis/*methods

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2016 Mar; Vol. 57 (2), pp. 114-24. Date of Electronic Publication: 2015 Dec 18.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Alterations of the lung methylome in allergic airway hyper-responsiveness.

Authors : Cheng RY; Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States.; Shang Y

Subjects: DNA Methylation*; Asthma/Asthma/Asthma/*immunology ; Hypersensitivity/Hypersensitivity/Hypersensitivity/*immunology

Source: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2014 Apr; Vol. 55 (3), pp. 244-55. Date of Electronic Publication: 2014 Jan 21.Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium:

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نتائج البحث

فلترة النتائج

PacBio sequencing detects genome-wide ultra-low-frequency substitution mutations resulting from exposure to chemical mutagens.

Methodologies for detecting environmentally induced DNA damage and repair.

A Return to the Origin of the EMGS: Rejuvenating the Quest for Human Germ Cell Mutagens and Determining the Risk to Future Generations.

Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk.

Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk.

Mutation as a Toxicological Endpoint for Regulatory Decision-Making.

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.

Development of a high-throughput genotoxicity assay using Umu test strains expressing human cytochrome P450s and NADPH-P450 reductase and bacterial O-acetyltransferase.

Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.

Alterations of the lung methylome in allergic airway hyper-responsiveness.

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