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Engineering Thermostable CYP2D Enzymes for Biocatalysis Using Combinatorial Libraries of Ancestors for Directed Evolution (CLADE).

• Authors : Gumulya, Yosephine^1,2; Huang, Weiliang¹; D'Cunha, Stephlina A.¹

• Source: ChemCatChem. 1/23/2019, Vol. 11 Issue 2, p841-850. 10p.

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Ethanol self‐administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.

• Authors : Miller, R. T.¹; Miksys, S.¹; Hoffmann, E.¹

• Source: British Journal of Pharmacology. Jun2014, Vol. 171 Issue 12, p3077-3088. 12p. 1 Black and White Photograph, 1 Chart, 3 Graphs.

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Is Cytochrome P450 CYP2D Activity Present Pig Liver?

• Authors : Skaanild, Mette T.; Friss, Christian

• Source: Pharmacology & Toxicology. Oct2002, Vol. 91 Issue 4, p198. 6p.

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Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.

• Authors : Tolledo, Edgor Cole¹ (AUTHOR); Miksys, Sharon¹ (AUTHOR); Gonzalez, Frank J.² (AUTHOR)

• Source: British Journal of Pharmacology. Feb2020, Vol. 177 Issue 3, p701-712. 12p. 1 Diagram, 6 Graphs.

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Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis–Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes.

• Authors : Chandrashekar, Devaraj Venkatapura¹ (AUTHOR); DuBois, Barent N.¹ (AUTHOR); Rashid, Mamunur¹ (AUTHOR)

• Source: Basic & Clinical Pharmacology & Toxicology. Feb2023, Vol. 132 Issue 2, p197-210. 14p.

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Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

• Authors : McMillan DM; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH) and Department of Pharmacology and Toxicology, University of Toronto, Canada.; Miksys S

Subjects: Analgesics, Opioid/Analgesics, Opioid/Analgesics, Opioid/*metabolism ; Brain/Brain/Brain/*physiology ; Cytochrome P450 Family 2/Cytochrome P450 Family 2/Cytochrome P450 Family 2/*metabolism

• Source: Addiction biology [Addict Biol] 2019 Mar; Vol. 24 (2), pp. 228-238. Date of Electronic Publication: 2017 Dec 21.Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9604935 Publication Model: Print-Electronic Cited

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Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

• Authors : Di Marco, Annalise¹; Dan Yao²; Laufer, Ralph¹

• Source: European Journal of Biochemistry. Sep2003, Vol. 270 Issue 18, p3768. 10p.

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High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation.

• Authors : Zahir, Maziar¹ (AUTHOR); Shariatzadeh, Siavash² (AUTHOR); Khosravi, Ayda¹ (AUTHOR)

• Source: Brain & Behavior. Aug2021, Vol. 11 Issue 8, p1-9. 9p.

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Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid.

• Authors : Stevison, Faith¹ (AUTHOR); Kosaka, Mika² (AUTHOR); Kenny, Jane R.² (AUTHOR)

• Source: CTS: Clinical & Translational Science. Jul2019, Vol. 12 Issue 4, p350-360. 11p.

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Influence of Gasoline Inhalation on the Enantioselective Pharmacokinetics of.

• Authors : Cardoso, Juciane Lauren Cavalcanti¹; Lanchote, Vera Lucia¹; Pereira, Maria Paula Marques¹

• Source: Chirality. Mar2013, Vol. 25 Issue 3, p206-210. 5p.

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