نتائج البحث

Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling.

• Authors : Qiu S; Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.; Jia Y

Subjects: Cyclopropanes/Cyclopropanes/Cyclopropanes/*pharmacology ; Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/*metabolism ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

• Source: Journal of diabetes research [J Diabetes Res] 2019 Feb 17; Vol. 2019, pp. 1897174. Date of Electronic Publication: 2019 Feb 17 (Print Publication: 2019).Publisher: Wiley Country of Publication: United States NLM ID: 101605237 Publication Model: eCollection Cited Medium:

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Identification and In Silico Analysis of Novel von Hippel-Lindau (VHL) Gene Variants from a Large Population

• Authors : Maddalena Martella; Silvio C. E. Tosatto; Emanuela Leonardi

Subjects: Genetics; medicine.medical_specialty; Cell growth

• Source: Annals of Human Genetics. 75:483-496

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Germline Mutation of von Hippel-Lindau (VHL) Gene 695 G>A (R161Q) in a Patient with a Peculiar Phenotype with Type 2C VHL Syndrome

• Authors : Daniela Lapa; Salvatore Benvenga; Libero Santarpia

Subjects: Adult; Pathology; medicine.medical_specialty

• Source: Annals of the New York Academy of Sciences. 1073:198-202

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Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

• Authors : Mathieu Johnson; Sandra Turcotte

Subjects: clear cell renal cell carcinoma; PIKfyve; pyroptosis

• Source: Molecular Oncology, Vol 19, Iss 4, Pp 1244-1264 (2025)

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Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin

• Authors : Urrutia, Andrés A; Guan, Nan; Mesa-Ciller, Claudia

Subjects: HIF; angiogenesis; brain

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Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor‐mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation

• Authors : Fuyan Xu; Jiao Li; Min Ai

Subjects: brain metastasis; cancerous inhibitor of protein phosphatase 2a; melanoma

• Source: MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)

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The protein tyrosine phosphatase PPH‐7 is required for fertility and embryonic development in C. elegans at elevated temperatures

• Authors : Curdin A. Franziscus; Danilo Ritz; N. Constantin Kappel

Subjects: C. elegans; phosphatase; phosphorylation

• Source: FEBS Open Bio, Vol 14, Iss 3, Pp 390-409 (2024)

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Renal cancer: signaling pathways and advances in targeted therapies

• Authors : Aimin Jiang; Jinxin Li; Ziwei He

Subjects: molecular mechanisms; precision medicine; renal cancer

• Source: MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)

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Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis

• Authors : Fei Song; Yu Hu; Yi‐Xiang Hong

Subjects: angiogenesis; cell proliferation; IGF1/IGF2

• Source: Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)

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Population pharmacokinetic analyses for belzutifan to inform dosing considerations and labeling

• Authors : Dhananjay D. Marathe; Petra M. Jauslin; Huub Jan Kleijn

Subjects: Therapeutics. Pharmacology; RM1-950

• Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1499-1510 (2023)

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