نتائج البحث

Predicting breast cancer prognosis based on a novel pathomics model through CHEK1 expression analysis using machine learning algorithms.

• Authors : Chen, Chen¹ (AUTHOR); Gao, Dan¹ (AUTHOR); Yue, Huan² (AUTHOR)

Subjects: *CHECKPOINT kinase 1; *FEATURE extraction; *BREAST cancer prognosis

• Source: PLoS ONE. 5/9/2025, Vol. 20 Issue 5, p1-24. 24p.

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The KRAS, ATR and CHEK1 expression levels in endometrial cancer are the risk factors predicting recurrence.

• Authors : Buchynska L; Department of Cancer Genetic and Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, Kyiv, Ukraine.; Gordiienko I

Subjects: Endometrial Neoplasms*/Endometrial Neoplasms*/Endometrial Neoplasms*/genetics ; Endometrial Neoplasms*/Endometrial Neoplasms*/Endometrial Neoplasms*/pathology ; Endometrial Neoplasms*/Endometrial Neoplasms*/Endometrial Neoplasms*/metabolism

• Source: PloS one [PLoS One] 2024 Apr 26; Vol. 19 (4), pp. e0302075. Date of Electronic Publication: 2024 Apr 26 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.

• Authors : Greer YE; Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, United States of America.; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, United States of America.

Subjects: DNA Damage* ; Down-Regulation* ; Genomic Instability*

• Source: PloS one [PLoS One] 2017 Jan 26; Vol. 12 (1), pp. e0170903. Date of Electronic Publication: 2017 Jan 26 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation.

• Authors : Kolb, Ryan H. (AUTHOR); Greer, Patrick M. (AUTHOR); Cao, Phu T. (AUTHOR)

Subjects: *DNA topoisomerase II; *DNA topoisomerase I; *CHECKPOINT kinase 1

• Source: PLoS ONE. 9/28/2023, Vol. 18 Issue 9, p1-9. 9p.

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Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling.

• Authors : Batzilla, Alina^1,2 (AUTHOR); Lu, Junyan^1,3,4 (AUTHOR) ; Kivioja, Jarno⁵ (AUTHOR)

• Source: PLoS Computational Biology. 8/22/2022, Vol. 18 Issue 8, p1-19. 19p. 2 Diagrams, 2 Graphs.

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A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy.

• Authors : Zhou, Jun¹; Chen, Zhengming¹; Malysa, Agnes¹

Subjects: *Nucleosides; *Pharmacodynamics; *Targeted drug delivery

• Source: PLoS ONE. Mar2013, Vol. 8 Issue 3, p1-11. 11p.

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p53 oligomerization status as an indicator of sensitivity of p53-wildtype neuroblastomas to the combination of DNA damaging agent and Chk1 inhibitor.

• Authors : Levesque, Aime A.¹ (AUTHOR) ; Pappalardo, Rebecca M.¹ (AUTHOR); Puli, Pawan¹ (AUTHOR)

Subjects: *Checkpoint kinase 1; *DNA damage; *Oligomerization

• Source: PLoS ONE. 2/10/2022, Vol. 17 Issue 2, p1-14. 14p.

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Genomic structure, expression, and functional characterization of checkpoint kinase 1 from Penaeus monodon.

• Authors : Qiu L; South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture, Guangzhou, China.; Key Laboratory of Aquatic Genomics, Ministry of Agriculture, Beijing, China.

Subjects: Gene Expression Regulation, Developmental*; Arthropod Proteins/Arthropod Proteins/Arthropod Proteins/*metabolism ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*genetics

• Source: PloS one [PLoS One] 2018 May 24; Vol. 13 (5), pp. e0198036. Date of Electronic Publication: 2018 May 24 (Print Publication: 2018).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Regulation of Mus81-Eme1 structure-specific endonuclease by Eme1 SUMO-binding and Rad3ATR kinase is essential in the absence of Rqh1BLM helicase.

• Authors : Giaccherini, Cédric¹ (AUTHOR); Scaglione, Sarah¹ (AUTHOR); Coulon, Stéphane¹ (AUTHOR)

• Source: PLoS Genetics. 4/22/2022, Vol. 18 Issue 4, p1-22. 22p.

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Ataxia telangiectasia and Rad3-related inhibition by AZD6738 enhances gemcitabine-induced cytotoxic effects in bladder cancer cells.

• Authors : Isono M; Department of Urology, National Defense Medical College, Tokorozawa, Japan.; Okubo K

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Combined Chemotherapy Protocols*/Antineoplastic Combined Chemotherapy Protocols*/Antineoplastic Combined Chemotherapy Protocols*/pharmacology ; Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/Ataxia Telangiectasia Mutated Proteins*/metabolism

• Source: PloS one [PLoS One] 2022 Apr 12; Vol. 17 (4), pp. e0266476. Date of Electronic Publication: 2022 Apr 12 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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