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Academic Journal

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Authors : Alrouji, Mohammed¹ (AUTHOR); Yasmin, Sabina² (AUTHOR); Alshammari, Mohammed S.³ (AUTHOR)

Source: PLoS ONE. 12/19/2024, Vol. 19 Issue 12, p1-19. 19p.

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Academic Journal

Modeling transthyretin (TTR) amyloid diseases, from monomer to amyloid fibrils.

Authors : Criddle, Richard S.¹ (AUTHOR); Hansen, Lee D.¹ (AUTHOR) ; Woodfield, Brian F.¹ (AUTHOR)

Source: PLoS ONE. 6/6/2024, Vol. 19 Issue 6, p1-14. 14p.

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Academic Journal

Computerized decision support is an effective approach to select memory clinic patients for amyloid-PET.

Authors : Rhodius-Meester, Hanneke F. M.^1,2,3,4 (AUTHOR) ; van Maurik, Ingrid S.^1,2,5,6 (AUTHOR); Collij, Lyduine E.⁷ (AUTHOR)

Source: PLoS ONE. 5/20/2024, Vol. 19 Issue 5, p1-17. 17p.

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Academic Journal

Design and synthesis of multi-functional small-molecule based inhibitors of amyloid-β aggregation: Molecular modeling and in vitro evaluation.

Authors : Radwan, Awwad A.^1,2 (AUTHOR) ; Alanazi, Fars K.^1,2 (AUTHOR); Raish, Mohammad² (AUTHOR)

Source: PLoS ONE. 5/25/2023, Vol. 17 Issue 5, p1-20. 20p.

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Academic Journal

Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App.

Authors : Pham, Hoa¹ (AUTHOR); Yin, Tao¹ (AUTHOR); D'Adamio, Luciano¹ (AUTHOR)

Source: PLoS ONE. 5/4/2022, Vol. 17 Issue 5, p1-30. 30p.

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Academic Journal

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.

Authors : Martiz, Reshma Mary^1,2 (AUTHOR); Patil, Shashank M.¹ (AUTHOR); Ramu, Ramith¹ (AUTHOR)

Source: PLoS ONE. 4/8/2022, Vol. 17 Issue 4, p1-18. 18p.

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Academic Journal

Calmodulin binds the N-terminus of the functional amyloid Orb2A inhibiting fibril formation.

Authors : Soria, Maria A.¹ (AUTHOR); Cervantes, Silvia A.¹ (AUTHOR); Siemer, Ansgar B.¹ (AUTHOR)

Source: PLoS ONE. 1/13/2022, Vol. 17 Issue 1, p1-12. 12p.

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Academic Journal

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

Authors : Parkin, Edward T.¹ (AUTHOR) ; Hammond, Jessica E.¹ (AUTHOR); Owens, Lauren¹ (AUTHOR)

Source: PLoS ONE. 1/13/2022, Vol. 17 Issue 1, p1-21. 21p.

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Academic Journal

Insights into the dynamic trajectories of protein filament division revealed by numerical investigation into the mathematical model of pure fragmentation.

Authors : Tournus, Magali¹ (AUTHOR) ; Escobedo, Miguel² (AUTHOR); Xue, Wei-Feng^3,4 (AUTHOR)

Source: PLoS Computational Biology. 9/3/2021, Vol. 17 Issue 9, p1-21. 21p. 7 Graphs.

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Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.

Authors : López-de-Eguileta, Alicia¹ (AUTHOR) ; Lage, Carmen² (AUTHOR); López-García, Sara² (AUTHOR)

Source: PLoS ONE. 9/21/2020, Vol. 15 Issue 9, p1-15. 15p.

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نتائج البحث

فلترة النتائج

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Modeling transthyretin (TTR) amyloid diseases, from monomer to amyloid fibrils.

Computerized decision support is an effective approach to select memory clinic patients for amyloid-PET.

Design and synthesis of multi-functional small-molecule based inhibitors of amyloid-β aggregation: Molecular modeling and in vitro evaluation.

Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App.

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.

Calmodulin binds the N-terminus of the functional amyloid Orb2A inhibiting fibril formation.

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

Insights into the dynamic trajectories of protein filament division revealed by numerical investigation into the mathematical model of pure fragmentation.

Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.

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