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Academic Journal

Insights into the dual nature of αB-crystallin chaperone activity from the p.P39L mutant at the N-terminal region.

Authors : Barati A; Protein Chemistry Laboratory (PCL), Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.; Rezaei Somee L

Subjects: Cardiomyopathies* ; Cataract*/Cataract*/Cataract*/genetics ; Crystallins*/Crystallins*/Crystallins*/genetics

Source: Scientific reports [Sci Rep] 2024 Mar 28; Vol. 14 (1), pp. 7353. Date of Electronic Publication: 2024 Mar 28.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Improve thermostability of Bacillus sp. TS chitosanase through structure-based alignment.

Authors : Zhou Z; Tianjin Sinonocy Biological Technology Co. Ltd., Tianjin, 300308, China.; Wang X

Subjects: Hot Temperature* ; Mutation*; Bacillus/Bacillus/Bacillus/*enzymology

Source: Scientific reports [Sci Rep] 2021 Aug 04; Vol. 11 (1), pp. 15846. Date of Electronic Publication: 2021 Aug 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis.

Authors : Sadr AS; Department of Computer and Data Sciences, Faculty of Mathematical Sciences, Shahid Beheshti University, Tehran, Iran.; Eslahchi C

Subjects: Computer Simulation* ; Mutation*; Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/*pathology

Source: Scientific reports [Sci Rep] 2021 Mar 25; Vol. 11 (1), pp. 6849. Date of Electronic Publication: 2021 Mar 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR CSTMLR mutant protein: molecular modeling and free energy approach.

Authors : Saini R; School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, 221005, India.; Kumari S

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics; Humans

Source: Scientific reports [Sci Rep] 2023 Jun 01; Vol. 13 (1), pp. 8885. Date of Electronic Publication: 2023 Jun 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells.

Authors : Ohmori T; Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.; De S

Subjects: Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/Induced Pluripotent Stem Cells/*metabolism ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*metabolism ; Mutant Proteins/Mutant Proteins/Mutant Proteins/*metabolism Nephrosis, congenital

Source: Scientific reports [Sci Rep] 2021 Feb 17; Vol. 11 (1), pp. 3982. Date of Electronic Publication: 2021 Feb 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies.

Authors : Vauleon S; Regulated Bioanalysis, Pharmaceutical Sciences, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd, Basel, Switzerland.; Schutz K

Subjects: Huntington Disease*/Huntington Disease*/Huntington Disease*/drug therapy ; Huntington Disease*/Huntington Disease*/Huntington Disease*/genetics ; Huntington Disease*/Huntington Disease*/Huntington Disease*/cerebrospinal fluid

Source: Scientific reports [Sci Rep] 2023 Apr 01; Vol. 13 (1), pp. 5332. Date of Electronic Publication: 2023 Apr 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.

Authors : Minei R; Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan.; Aoki H

Subjects: Brain*/Brain*/Brain*/growth & development ; Proto-Oncogene Proteins c-kit*/Proto-Oncogene Proteins c-kit*/Proto-Oncogene Proteins c-kit*/genetics ; Proto-Oncogene Proteins c-kit*/Proto-Oncogene Proteins c-kit*/Proto-Oncogene Proteins c-kit*/metabolism

Source: Scientific reports [Sci Rep] 2023 Mar 13; Vol. 13 (1), pp. 4166. Date of Electronic Publication: 2023 Mar 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.

Authors : Murcia JDG; Brigham Young University, Department of Biology, 4102 Life Sciences Building, Provo, Utah, 84602, USA.; Weinert A

Subjects: Mutant Proteins*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*etiology ; Chemokine CCL2/Chemokine CCL2/Chemokine CCL2/*metabolism

Source: Scientific reports [Sci Rep] 2020 May 15; Vol. 10 (1), pp. 8019. Date of Electronic Publication: 2020 May 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation.

Authors : Hoch L; CECS, I-Stem, 91100, Corbeil-Essonnes, France.; INSERM U861, I-Stem, 91100, Corbeil-Essonnes, France.

Subjects: Mutant Proteins/Mutant Proteins/Mutant Proteins/*chemistry ; Mutant Proteins/Mutant Proteins/Mutant Proteins/*metabolism ; Protein Folding/Protein Folding/Protein Folding/*drug effects

Source: Scientific reports [Sci Rep] 2019 May 06; Vol. 9 (1), pp. 6915. Date of Electronic Publication: 2019 May 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib.

Authors : Nannini M; Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.; Tarantino G

Subjects: INDEL Mutation*; Gastrointestinal Neoplasms/Gastrointestinal Neoplasms/Gastrointestinal Neoplasms/*enzymology ; Gastrointestinal Neoplasms/Gastrointestinal Neoplasms/Gastrointestinal Neoplasms/*genetics

Source: Scientific reports [Sci Rep] 2019 Feb 18; Vol. 9 (1), pp. 2172. Date of Electronic Publication: 2019 Feb 18.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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نتائج البحث

فلترة النتائج

Insights into the dual nature of αB-crystallin chaperone activity from the p.P39L mutant at the N-terminal region.

Improve thermostability of Bacillus sp. TS chitosanase through structure-based alignment.

In silico studies reveal structural deviations of mutant profilin-1 and interaction with riluzole and edaravone in amyotrophic lateral sclerosis.

Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR CSTMLR mutant protein: molecular modeling and free energy approach.

Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells.

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies.

Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.

Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.

Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation.

Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib.

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