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Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect

• Authors : Olley, Gabrielle; Pradeepa, Madapura; Grimes, Graeme ...

Subjects: Cornelia de Lange syndrome; CDLS; BRD4

• Source: ISSN: 2041-1723.

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Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4

• Authors : Amy Nagelberg; William W. Lockwood; Daniel Lu

Subjects: 0301 basic medicine; Cancer Research; BRD4

• Source: Oncogenesis, Vol 10, Iss 3, Pp 1-15 (2021)Oncogenesis

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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

• Authors : SEGATTO, MARCO; Fittipaldi, Raffaella; Pin, Fabrizio ...

Subjects: cancer cachexia; BET; BRD4

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Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors

• Authors : Donato E; Croci O; Sabò A ...

Subjects: MYC; BRD4; BET inhibitor

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YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer.

• Authors : Yamazaki M; Department of Medical Biochemistry, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Hino S

Subjects: Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/metabolism ; Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/Carcinoma, Pancreatic Ductal*/genetics; Humans

• Source: The EMBO journal [EMBO J] 2023 Jul 17; Vol. 42 (14), pp. e112614. Date of Electronic Publication: 2023 Apr 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited

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BRD4-PRC2 represses transcription of T-helper 2-specific negative regulators during T-cell differentiation.

• Authors : Zhao L; Institute of Epigenetic Medicine, First Hospital of Jilin University, Changchun, China.; Wang Y

Subjects: Polycomb Repressive Complex 2*/Polycomb Repressive Complex 2*/Polycomb Repressive Complex 2*/metabolism ; Nuclear Proteins*/Nuclear Proteins*/Nuclear Proteins*/metabolism; Mice

• Source: The EMBO journal [EMBO J] 2023 Mar 15; Vol. 42 (6), pp. e111473. Date of Electronic Publication: 2023 Jan 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited

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Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors

Subjects: MYC, BRD4, BET inhibitor, JQ1, RNA polymerase II, B-cell tumor; BIO/11 - BIOLOGIA MOLECOLARE; info:eu-repo/semantics/article

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BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses.

• Authors : Dey A; Division of Developmental Biology, National Institute of Child Health and Human Development, Bethesda, MD, USA.; Yang W

Subjects: Gene Expression Regulation*; Biomarkers/Biomarkers/Biomarkers/*analysis ; Hematopoietic Stem Cells/Hematopoietic Stem Cells/Hematopoietic Stem Cells/*cytology

• Source: The EMBO journal [EMBO J] 2019 Apr 01; Vol. 38 (7). Date of Electronic Publication: 2019 Mar 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited

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