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A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.

• Authors : Dongjun Liang^1,2; Kane Wu^1,2; Reika Tei^1,2

Subjects: *PHOSPHOLIPASE D; *CLICK chemistry; *G protein coupled receptors

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/30/2019, Vol. 116 Issue 31, p15453-15462. 10p.

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Click chemistry–enabled CRISPR screening reveals GSK3 as a regulator of PLD signaling.

• Authors : Bumpus, Timothy W.¹; Shiying Huang¹; Tei, Reika¹

Subjects: *GLYCOGEN synthase kinase; *CRISPRS; *PROTEIN kinase C

• Source: Proceedings of the National Academy of Sciences of the United States of America. 11/30/2021, Vol. 118 Issue 48, p1-7. 7p.

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Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor.

• Authors : Hirose, Tomoyasu¹; Maita, Nobuo²; Gouda, Hiroaki³

Subjects: *CLICK chemistry; *CHITINASE; *RING formation (Chemistry)

• Source: Proceedings of the National Academy of Sciences of the United States of America. 10/1/2013, Vol. 110 Issue 40, p15892-15897. 6p.

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Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo.

• Authors : Vaidya, Aditya S.^1,2; Peterson, Francis C.³; Eckhardt, James^1,2

Subjects: *ABSCISIC acid; *CLICK chemistry; *PLANT hormones

• Source: Proceedings of the National Academy of Sciences of the United States of America. 9/21/2021, Vol. 118 Issue 38, p1-7. 7p.

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Identification of simple arylfluorosulfates as potent agents against resistant bacteria.

• Authors : Jiong Zhang¹; Xiangxiang Zhao²; Cappiello, John R.³

Subjects: *CLICK chemistry; *ANTIBACTERIAL agents; *MULTIDRUG resistance

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/13/2021, Vol. 118 Issue 28, p1-7. 7p.

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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.

• Authors : Qinheng Zheng¹; Woehl, Jordan L.²; Kitamura, Seiya²

Subjects: *LEUCOCYTE elastase; *CLICK chemistry; *BIOLOGICAL assay

• Source: Proceedings of the National Academy of Sciences of the United States of America. 9/17/2019, Vol. 116 Issue 38, p18808-18814. 7p.

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Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.

• Authors : Greaves, Jennifer¹; Chamberlain, uke H.¹; Munro, Kevin R.²

Subjects: *ACYLATION; *FATTY acid analysis; *ZINC enzymes

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/21/2017, Vol. 114 Issue 8, pE1365-E1374. 10p.

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A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity

• Authors : Liang, Dongjun; Wu, Kane; Tei, Reika

Subjects: PNAS Plus

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Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry

• Authors : Luo, Haiming; Hernandez, Reinier; Hong, Hao

Subjects: Biological Sciences

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Semisynthetic protein nanoreactor for single-molecule chemistry.

• Authors : Joongoo Lee¹; Bayley, Hagan¹

Subjects: *SINGLE molecules; *CLICK chemistry; *ALKYNES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 11/10/2015, Vol. 112 Issue 45, p13768-13773. 6p.

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Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity.

• Authors : Wagner, Koen¹; Kwakkenbos, Mark J.¹; Claassen, Yvonne B.¹

Subjects: *BISPECIFIC antibodies; *IMMUNOGLOBULINS; *SORTASES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 11/25/2014, Vol. 111 Issue 47, p16820-16825. 6p.

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Copper-free click chemistry in living animals

• Authors : Chang, Pamela V.; Prescher, Jennifer A.; Sletten, Ellen M.

Subjects: Physical Sciences

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Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry.

• Authors : Haiming Luo¹; Hernandez, Reinier²; Hao Hong¹

Subjects: *BRAIN cancer research; *CANCER diagnosis; *GLIOBLASTOMA multiforme

• Source: Proceedings of the National Academy of Sciences of the United States of America. 10/13/2015, Vol. 112 Issue 41, p12806-12811. 6p.

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Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping.

• Authors : Hailei Zhang; Huan Zhong; Xufeng Wang

Subjects: RNA; GENETIC regulation; CLICK chemistry

• Source: Proceedings of the National Academy of Sciences of the United States of America; 4/6/2021, Vol. 118 Issue 14, p1-11, 11p

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Exploring RNA transcription and turnover in vivo by using click chemistry

• Authors : Jao, Cindy Y.; Salic, Adrian

Subjects: Biological Sciences

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Copper-free click chemistry for dynamic in vivo imaging

• Authors : Baskin, Jeremy M.; Prescher, Jennifer A.; Laughlin, Scott T.

Subjects: Physical Sciences

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Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.

• Authors : Ottonello, Alessandra¹; Wyllie, Jessica A.¹; Yahiaoui, Oussama²

Subjects: *GRAM-positive bacteria; *BACTERIAL cell walls; *ANTIBIOTICS

• Source: Proceedings of the National Academy of Sciences of the United States of America. 4/11/2023, Vol. 120 Issue 15, p1-8. 76p.

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Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide.

• Authors : Teruhiko Matsubara; Michiko Ujie; Takashi Yamamoto

Subjects: INFLUENZA viruses; SIALIC acids; IMPEDANCE spectroscopy

• Source: Proceedings of the National Academy of Sciences of the United States of America; 8/9/2016, Vol. 113 Issue 32, p8981-8984, 4p

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Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.

• Authors : Kropp, Heike Maria; Dürr, Simon Leonard; Peter, Christine

Subjects: DNA polymerases; NUCLEOTIDES; PHOTOGRAPHS

• Source: Proceedings of the National Academy of Sciences of the United States of America; 10/2/2018, Vol. 115 Issue 40, p9992-9997, 6p

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Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

• Authors : Ismail, Hanafy M.; Barton, Victoria; Phanchana, Matthew

Subjects: ARTEMISININ; PLASMODIUM falciparum genetics; ANTIMALARIALS

• Source: Proceedings of the National Academy of Sciences of the United States of America; 2/23/2016, Vol. 113 Issue 8, p2080-2085, 6p

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Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry.

• Authors : Wheat, Andrew¹; Clinton Yu¹; Xiaorong Wang¹

Subjects: *PROTEIN-protein interactions; *SPECTROMETRY; *LANDSCAPES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 8/10/2021, Vol. 118 Issue 32, p1-12. 12p.

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Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cell labeling and targeted treatment via in vivo click reaction.

• Authors : Yang Bo¹; Jingyi Zhou¹; Kaimin Cai^1,2

Subjects: *ENDOENZYMES; *CANCER cells; *TRIPLE-negative breast cancer

• Source: Proceedings of the National Academy of Sciences of the United States of America. 9/5/2023, Vol. 120 Issue 36, p1-12. 59p.

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High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells.

• Authors : Zorkau, Matthew¹; Albus, Christin A.¹; Berlinguer-Palmini, Rolando²

Subjects: *PROTEIN synthesis; *MITOCHONDRIAL proteins; *HUMAN cell culture

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/9/2021, Vol. 118 Issue 6, p1-9. 9p.

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High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells

• Authors : Robert N. Lightowlers; Christin A. Albus; Rolando Berlinguer-Palmini

Subjects: Mitochondrial DNA; protein synthesis; RNA, Mitochondrial

• Source: Proceedings of the National Academy of Sciences of the United States of AmericaProceedings of the National Academy of Sciences

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Semibatch monomer addition as a general method to tune and enhance the mechanics of polymer networks via loop-defect control.

• Authors : Yuwei Gu; Ken Kawamoto; Mao Chen

Subjects: COLLOIDS; LOOPS (Group theory); POLYMER networks

• Source: Proceedings of the National Academy of Sciences of the United States of America; 5/9/2017, Vol. 114 Issue 19, p4875-4880, 6p, 1 Color Photograph, 1 Chart, 2 Graphs

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Snapshots of a modified nucleotide moving through the confines of a DNA polymerase

• Authors : Kay Diederichs; Simon Leonard Dürr; Andreas Marx

Subjects: 0301 basic medicine; Models, Molecular; DNA polymerase

• Source: Proceedings of the National Academy of Sciences of the United States of America

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Visualizing in situ translational activity for identifying and sorting slow-growing archaeal−bacterial consortia

• Authors : Hatzenpichler, Roland; Connon, Stephanie A.; Goudeau, Danielle

Subjects: activity-based cell sorting; BONCAT; click chemistry

• Source: Proceedings of the National Academy of Sciences of the United States of America, 113(28), E4069-E4078, (2016-07-12)

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Cell-Specific Proteomic Analysis in Caenorhabditis elegans

• Authors : Yuet, Kai P.; Doma, Meenakshi K.; Ngo, John T.

Subjects: click chemistry; protein engineering; proteomics

• Source: Proceedings of the National Academy of Sciences of the United States of America, 112(9), 2705-2710, (2015-03-03)

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Enhanced incorporation of subnanometer tags into cellular proteins for fluorescence nanoscopy via optimized genetic code expansion.

• Authors : Mihaila, Tiberiu S.¹; Bäte, Carina¹; Ostersehlt, Lynn M.¹

Subjects: *GENETIC code; *TRANSFER RNA; *PROTEINS

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/19/2022, Vol. 119 Issue 29, p1-64. 74p.

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Identification of secreted bacterial proteins by noncanonical amino acid tagging

• Authors : Mahdavi, Alborz; Szychowski, Janek; Ngo, John T.

Subjects: proteomics; click chemistry; BONCAT

• Source: Proceedings of the National Academy of Sciences of the United States of America, 111(1), 433-438, (2014-01-07)

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Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo

• Authors : Tanrikulu, I. Caglar; Schmitt, Emmanuelle; Mechulam, Yves

Subjects: click chemistry; high-throughput screening; protein engineering

• Source: Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15285-15290, (2009-09-08)

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Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions

• Authors : Zhang, Wenyu; Dichtel, William R.; Steig, Adam Z.

Subjects: click chemistry; foldamers; polymers

• Source: Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6514-6519, (2008-05-06)

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Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids

• Authors : Link, A. James; Vink, Mandy K. S.; Agard, Nicholas J.

Subjects: azide–alkyne ligation; azidohomoalanine; azidonorleucine

• Source: Proceedings of the National Academy of Sciences of the United States of America, 103(27), 10180-10185, (2006-07-05)

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Universal inverse design of surfaces with thin nematic elastomer sheets.

• Authors : Aharoni, Hillel¹; Kamien, Randall D.¹; Yu Xia²

Subjects: *ELASTOMERS; *FLEXIBLE electronics; *HYDROGELS

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/10/2018, Vol. 115 Issue 28, p7206-7211. 6p.

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A chemical method for fast and sensitive detection of DNA synthesis in vivo.

• Authors : Salic, Adrian¹ ; Mitchison, Timothy J.²

Subjects: *DNA synthesis; *CELLS; *AZIDES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/19/2008, Vol. 105 Issue 7, p2415-2420. 6p. 31 Black and White

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Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.

• Authors : Tsui-Ling Hsu^1,2; Hanson, Sarah R.¹; Kishikawa, Kuniyuki¹

Subjects: *GLYCOSYLATION; *CANCER; *OLIGOSACCHARIDES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/20/2007, Vol. 104 Issue 8, p2614-2619. 6p. 1 Diagram, 13 Graphs.

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Superresolution imaging of individual replication forks reveals unexpected prodrug resistance mechanism.

• Authors : Triemer, Therese¹; Messikommer, Alessandra¹; Glasauer, Stella M. K.¹

Subjects: *NUCLEOSIDES; *PRODRUGS; *CYTARABINE

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/13/2018, Vol. 115 Issue 7, pE1366-E1373. 8p.

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Detouring of cisplatin to access mitochondrial genome for overcoming resistance.

• Authors : Marrache, Sean¹; Pathak, Rakesh K.¹; Dhar, Shanta^1,2

Subjects: *CISPLATIN; *ALKYLATING agents; *MITOCHONDRIAL pathology

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/22/2014, Vol. 111 Issue 29, p10444-10449. 6p.

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Hydrogel drug delivery system with predictable and tunable drug release and degradation rates.

• Authors : Ashley, Gary W.¹; Henise, Jeff¹; Reid, Ralph¹

Subjects: *DRUG delivery systems; *HYDROGELS; *PROTEINS

• Source: Proceedings of the National Academy of Sciences of the United States of America. 2/5/2013, Vol. 110 Issue 6, p2318-2323. 6p.

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Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin.

• Authors : Jing Liu¹; Yangqing Xu¹; Stoleru, Dan²

Subjects: *PROTEIN synthesis; *ALKYNES; *PUROMYCIN

• Source: Proceedings of the National Academy of Sciences of the United States of America. 1/10/2012, Vol. 109 Issue 2, p413-418. 6p.

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Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.

• Authors : El-Sagheer, Afaf H.^1,2; Sanzone, A. Pia¹; Gao, Rachel¹

Subjects: *ESCHERICHIA coli; *DNA polymerases; *TRIAZOLES

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/12/2011, Vol. 108 Issue 28, p11338-11343. 6p.

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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells.

• Authors : Ying-Chih Liu^1,2; Hsin-Yung Yen^1,2; Chien-Yu Chen^1,2

Subjects: *LUNG cancer; *SIALIC acids; *MASS spectrometry

• Source: Proceedings of the National Academy of Sciences of the United States of America. 7/12/2011, Vol. 108 Issue 28, p11332-11337. 6p.

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Chemical reporters for fluorescent detection and identification of O-GIcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1.

• Authors : Zaro, Balyn W.¹; Yu-Ying Yang²; Hang, Howard C.²

Subjects: *PROTEIN synthesis; *BIOSYNTHESIS; *GLYCOSYLATION

• Source: Proceedings of the National Academy of Sciences of the United States of America. 5/17/2011, Vol. 108 Issue 20, p8146-8151. 6p.

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Targeted metabolic labeling of yeast N-glycans with unnatural sugars.

• Authors : Breidenbach, Mark A.¹; Gallagher, Jennifer E. G.²; King, David S.³

Subjects: *GLYCOSYLATION; *SUGARS; *GLYCOPROTEINS

• Source: Proceedings of the National Academy of Sciences of the United States of America. 3/2/2010, Vol. 107 Issue 9, p3988-3993. 6p.

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Folding of a donor-acceptor polyrotaxane by using noncovalent bonding interactions.

• Authors : Wenyu Zhang¹; Dichtel, William R.^1,2; Stieg, Adam Z.¹

Subjects: *ROTAXANES; *CATENANES; *ELECTROMECHANICAL devices

• Source: Proceedings of the National Academy of Sciences of the United States of America. 5/6/2008, Vol. 105 Issue 18, p3514-6519. 6p. 3 Diagrams, 3 Charts, 3

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Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors

• Authors : Cheng, Yunfei; Li, Gencheng; Smedley, Christopher J.

Subjects: Physical Sciences

• Source: Proc Natl Acad Sci U S A

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NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of proteincoding genes in Arabidopsis.

• Authors : Hailei Zhang¹; Huan Zhong¹; Shoudong Zhang^1,2,3

Subjects: *ARABIDOPSIS; *CHEMICAL reactions; *RNA

• Source: Proceedings of the National Academy of Sciences of the United States of America. 6/11/2019, Vol. 116 Issue 24, p12072-12077. 6p.

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Transcriptome-wide discovery of coding and noncoding RNA-binding proteins.

• Authors : Rongbing Huang^1,2; Mengting Han^1,2; Liying Meng^1,3

Subjects: *NON-coding RNA; *RNA-binding proteins; *GENETIC regulation

• Source: Proceedings of the National Academy of Sciences of the United States of America. 4/24/2018, Vol. 115 Issue 17, pE3879-E3887. 9p.

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Revealing nascent proteomics in signaling pathways and cell differentiation.

• Authors : Forester, Craig M.^1,2,3; Qian Zhao^4,5; Phillips, Nancy J.⁴

Subjects: *PROTEOMICS; *CELLULAR signal transduction; *CELL differentiation

• Source: Proceedings of the National Academy of Sciences of the United States of America. 3/6/2018, Vol. 115 Issue 10, p2353-2358. 6p.

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Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window.

• Authors : Shoujun Zhu¹; Antaris, Alexander L.¹; Jingying Yue¹

Subjects: *MOLECULAR crystals; *BIOCONJUGATES; *DENSITY functionals

• Source: Proceedings of the National Academy of Sciences of the United States of America. 1/31/2017, Vol. 114 Issue 5, p962-967. 6p.

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