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PDE3A as a Therapeutic Target for the Modulation of Compartmentalised Cyclic Nucleotide-Dependent Signalling.

• Authors : Pati, Swaroop Ranjan^1,2 (AUTHOR); Sholokh, Anastasiia^1,2,3 (AUTHOR); Klussmann, Enno^1,3 (AUTHOR)

• Source: Cells (2073-4409). Jun2025, Vol. 14 Issue 11, p771. 20p.

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Evolutionary Origins and Functional Diversification of 2'-O-Methyltransferases: Insights from Phylogenetic and Structural Analysis.

• Authors : Wang SN; School of Life Sciences, Nanjing University, Nanjing 210023, China.; Liu XX

Subjects: Methyltransferases*/Methyltransferases*/Methyltransferases*/genetics ; Methyltransferases*/Methyltransferases*/Methyltransferases*/chemistry ; Methyltransferases*/Methyltransferases*/Methyltransferases*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 30; Vol. 26 (11). Date of Electronic Publication: 2025 May 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Substrate Activation Efficiency in Active Sites of Hydrolases Determined by QM/MM Molecular Dynamics and Neural Networks.

• Authors : Polyakov IV; Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.; Meteleshko YI

Subjects: Neural Networks, Computer* ; Molecular Dynamics Simulation* ; Hydrolases*/Hydrolases*/Hydrolases*/chemistry

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 26; Vol. 26 (11). Date of Electronic Publication: 2025 May 26.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Valence Bond Insights into the H-Abstraction Barrier in Cytochrome P450.

• Authors : Zhang E; Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.; Hirao H

Subjects: Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/chemistry ; Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/Cytochrome P-450 Enzyme System*/metabolism ; Hydrogen*/Hydrogen*/Hydrogen*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 21; Vol. 30 (10). Date of Electronic Publication: 2025 May 21.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Chondrosarcoma: Multi-Targeting Therapeutic Effects of Doxorubicin, BEZ235, and the Small Molecule Aspartyl-Asparaginyl-β-hydroxylase Inhibitor SMI1182.

• Authors : Fife M; Molecular Pharmacology, Physiology, and Biotechnology Graduate Program, Brown University, Providence, RI 02912, USA.; Tong M

• Source: Cancers [Cancers (Basel)] 2025 May 15; Vol. 17 (10). Date of Electronic Publication: 2025 May 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print

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FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells.

• Authors : Barré, Lydia¹ (AUTHOR); Shaukat, Irfan¹ (AUTHOR); Ouzzine, Mohamed (AUTHOR)

• Source: Cells (2073-4409). May2025, Vol. 14 Issue 10, p712. 21p.

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Crystal Structure of the Multidomain Pectin Methylesterase PmeC5 from Butyrivibrio fibrisolvens D1 T .

• Authors : Carbone V; AgResearch Limited, Grasslands Research Centre, Palmerston North 4442, New Zealand.; Reilly K

Subjects: Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/chemistry ; Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/metabolism ; Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/Carboxylic Ester Hydrolases*/genetics

• Source: Biomolecules [Biomolecules] 2025 May 14; Vol. 15 (5). Date of Electronic Publication: 2025 May 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium:

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Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors.

• Authors : Wang H; School of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China.; Cai W

Subjects: Matrix Metalloproteinase Inhibitors*/Matrix Metalloproteinase Inhibitors*/Matrix Metalloproteinase Inhibitors*/pharmacology ; Matrix Metalloproteinase Inhibitors*/Matrix Metalloproteinase Inhibitors*/Matrix Metalloproteinase Inhibitors*/chemistry ; Peptides*/Peptides*/Peptides*/chemistry

• Source: Biomolecules [Biomolecules] 2025 May 12; Vol. 15 (5). Date of Electronic Publication: 2025 May 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium:

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Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA.

• Authors : Ouzon-Shubeita H; The Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.; Barnes R

Subjects: Thymine*/Thymine*/Thymine*/chemistry ; Excision Repair* ; Endodeoxyribonucleases*/Endodeoxyribonucleases*/Endodeoxyribonucleases*/chemistry

• Source: Molecules (Basel, Switzerland) [Molecules] 2025 May 07; Vol. 30 (9). Date of Electronic Publication: 2025 May 07.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Genome-Wide Identification and Functional Analysis of the Norcoclaurine Synthase Gene Family in Aristolochia contorta .

• Authors : Xu Y; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.; Key Lab of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

Subjects: Aristolochia*/Aristolochia*/Aristolochia*/genetics ; Aristolochia*/Aristolochia*/Aristolochia*/enzymology ; Aristolochia*/Aristolochia*/Aristolochia*/metabolism

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 01; Vol. 26 (9). Date of Electronic Publication: 2025 May 01.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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