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Academic Journal

Multipotent Effect of Clozapine on Lipopolysaccharide-Induced Acetylcholinesterase, Cyclooxygenase-2,5-Lipoxygenase, and Caspase-3: In Vivo and Molecular Modeling Studies.

Authors : Arfeen M; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia.; Dhaked DK

Subjects: Lipopolysaccharides* ; Molecular Docking Simulation* ; Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/metabolism

Source: Molecules (Basel, Switzerland) [Molecules] 2025 Jan 11; Vol. 30 (2). Date of Electronic Publication: 2025 Jan 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Academic Journal

Interactions between Inhibitors and 5-Lipoxygenase: Insights from Gaussian Accelerated Molecular Dynamics and Markov State Models.

Authors : Liu Y; Edmond H. Fischer Signal Transduction Laboratory, School of Life Sciences, Jilin University, Changchun 130012, China.; Wang K

Subjects: Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/metabolism ; Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/Arachidonate 5-Lipoxygenase*/chemistry ; Molecular Dynamics Simulation*

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 30; Vol. 25 (15). Date of Electronic Publication: 2024 Jul 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Academic Journal

Polyphenolic Profile of Callistemon viminalis Aerial Parts: Antioxidant, Anticancer and In Silico 5-LOX Inhibitory Evaluations.

Authors : Mahgoub S; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt.; Hashad N

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Antioxidants/Antioxidants/Antioxidants/*chemistry ; Arachidonate 5-Lipoxygenase/Arachidonate 5-Lipoxygenase/Arachidonate 5-Lipoxygenase/*drug effects

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Apr 24; Vol. 26 (9). Date of Electronic Publication: 2021 Apr 24.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Academic Journal

Exploring Biological Activity of 4-Oxo-4 H -furo[2,3- h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.

Authors : Mphahlele MJ; Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, Private Bag X06, Florida 1710, South Africa.; Agbo EN

Subjects: Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/chemistry ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism

Source: Biomolecules [Biomolecules] 2019 Nov 13; Vol. 9 (11). Date of Electronic Publication: 2019 Nov 13.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium:

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Academic Journal

In Vitro Evaluation and In Silico Calculations of the Antioxidant and Anti-Inflammatory Properties of Secondary Metabolites from Leonurus sibiricus L. Root Extracts.

Authors : Merecz-Sadowska A; Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.; Sitarek P

Subjects: Antioxidants*/Antioxidants*/Antioxidants*/pharmacology ; Leonurus*; Humans

Source: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 10; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 10.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Academic Journal

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A 4 Hydrolase.

Authors : Teder T; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.; König S

Subjects: Epoxide Hydrolases*/Epoxide Hydrolases*/Epoxide Hydrolases*/metabolism ; Chalcogens*; Leukotriene A4

Source: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 19; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 19.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Academic Journal

Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation.

Authors : Dufrusine B; Department of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.; Department of Innovative Technologies in Medicine and Dentistry, University 'G. d'Annunzio' of Chieti-Pescara, 66100 Chieti, Italy.

Subjects: Iron*/Iron*/Iron*/metabolism ; COVID-19*; Humans

Source: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 20; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 20.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium:

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Academic Journal

Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling.

Authors : Chen M; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.; Wang L

Subjects: Cytochromes c*/Cytochromes c*/Cytochromes c*/metabolism ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism; Animals

Source: Cells [Cells] 2022 Sep 29; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium:

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Academic Journal

Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages.

Authors : Assaggaf HM; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Naceiri Mrabti H

Subjects: Oils, Volatile*/Oils, Volatile*/Oils, Volatile*/chemistry ; Salvia officinalis*/Salvia officinalis*/Salvia officinalis*/chemistry; Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/chemistry

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 12; Vol. 27 (16). Date of Electronic Publication: 2022 Aug 12.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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Academic Journal

Singular and Combined Effects of Essential Oil and Honey of Eucalyptus Globulus on Anti-Inflammatory, Antioxidant, Dermatoprotective, and Antimicrobial Properties: In Vitro and In Vivo Findings.

Authors : Assaggaf HM; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Naceiri Mrabti H

Subjects: Anti-Infective Agents*/Anti-Infective Agents*/Anti-Infective Agents*/pharmacology ; Eucalyptus*/Eucalyptus*/Eucalyptus*/chemistry ; Honey*

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 11; Vol. 27 (16). Date of Electronic Publication: 2022 Aug 11.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium:

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فلترة النتائج

Multipotent Effect of Clozapine on Lipopolysaccharide-Induced Acetylcholinesterase, Cyclooxygenase-2,5-Lipoxygenase, and Caspase-3: In Vivo and Molecular Modeling Studies.

Interactions between Inhibitors and 5-Lipoxygenase: Insights from Gaussian Accelerated Molecular Dynamics and Markov State Models.

Polyphenolic Profile of Callistemon viminalis Aerial Parts: Antioxidant, Anticancer and In Silico 5-LOX Inhibitory Evaluations.

Exploring Biological Activity of 4-Oxo-4 H -furo[2,3- h ]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.

In Vitro Evaluation and In Silico Calculations of the Antioxidant and Anti-Inflammatory Properties of Secondary Metabolites from Leonurus sibiricus L. Root Extracts.

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A 4 Hydrolase.

Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation.

Mitochondrion-Mediated Cell Death through Erk1-Alox5 Independent of Caspase-9 Signaling.

Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages.

Singular and Combined Effects of Essential Oil and Honey of Eucalyptus Globulus on Anti-Inflammatory, Antioxidant, Dermatoprotective, and Antimicrobial Properties: In Vitro and In Vivo Findings.

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