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Academic Journal

Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2.

Authors : Haron MH; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS, USA.; Dale O

Subjects: Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/metabolism ; Receptors, Steroid*/Receptors, Steroid*/Receptors, Steroid*/metabolism; Humans

Source: Journal of dietary supplements [J Diet Suppl] 2023; Vol. 20 (5), pp. 763-776. Date of Electronic Publication: 2022 Aug 26.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101249830 Publication Model: Print-Electronic Cited

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Academic Journal

Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Authors : Li SC; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.

Subjects: Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/metabolism ; Aryl Hydrocarbon Hydroxylases*/Aryl Hydrocarbon Hydroxylases*/Aryl Hydrocarbon Hydroxylases*/metabolism; Rats

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 207-214. Date of Electronic Publication: 2023 May 15.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro .

Authors : Burkina V; Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.; Zamaratskaia G

Subjects: Curcumin* ; Cytochrome P-450 CYP1A2*; Animals

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2022 May; Vol. 52 (5), pp. 435-441. Date of Electronic Publication: 2022 Jul 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes.

Authors : Zhou Y; Department of Pharmacy, Shanghai Baoshan Luodian Hospital, Shanghai, China.; Xian Q

Subjects: Cytochrome P-450 CYP1A2* ; Microsomes, Liver*; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/pharmacology

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Dec; Vol. 51 (12), pp. 1360-1365. Date of Electronic Publication: 2021 Nov 28.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo.

Authors : Li S; Sichuan Animal Science Academy, Chengdu, China.; Li X

Subjects: Aryl Hydrocarbon Hydroxylases* ; Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/genetics; Animals

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 961-967. Date of Electronic Publication: 2021 Aug 02.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation.

Authors : Barrangou-Poueys-Darlas M; Clinical Pharmacology Department, University Hospital Centre Nantes, Nantes, France.; Guerlais M

Subjects: Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/pharmacology ; Smoking Cessation*/Smoking Cessation*/Smoking Cessation*/methods; Drug Interactions

Source: Drug metabolism reviews [Drug Metab Rev] 2021 Feb; Vol. 53 (1), pp. 30-44. Date of Electronic Publication: 2021 Jan 04.Publisher: Informa Healthcare Country of Publication: England NLM ID: 0322067 Publication Model: Print-Electronic Cited

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Academic Journal

Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate.

Authors : Nishimuta H; a Preclinical Research Unit , Sumitomo Dainippon Pharma Co. Ltd. , Osaka , Japan.; Sato K

Subjects: Cytochrome P-450 CYP1A2/Cytochrome P-450 CYP1A2/Cytochrome P-450 CYP1A2/*chemistry ; Cytochrome P-450 CYP1A2 Inhibitors/Cytochrome P-450 CYP1A2 Inhibitors/Cytochrome P-450 CYP1A2 Inhibitors/*chemistry ; Selective Serotonin Reuptake Inhibitors/Selective Serotonin Reuptake Inhibitors/Selective Serotonin Reuptake Inhibitors/*chemistry

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jun; Vol. 49 (6), pp. 636-645. Date of Electronic Publication: 2018 Jul 23.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver.

Authors : Zhang Y; Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.; WPI Nano Life Science Institute, Kanazawa University, Kanazawa, Japan.

Subjects: Cytochromes*/Cytochromes*/Cytochromes*/metabolism; Catalysis ; Cytochrome P-450 CYP1A2/Cytochrome P-450 CYP1A2/Cytochrome P-450 CYP1A2/metabolism

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Dec; Vol. 51 (12), pp. 1352-1359. Date of Electronic Publication: 2021 Nov 30.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation.

Authors : Uno Y; Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.; Uehara S

Subjects: Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/Cytochrome P-450 CYP1A2*/metabolism ; Omeprazole*/Omeprazole*/Omeprazole*/metabolism; Humans

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Dec; Vol. 53 (6-7), pp. 465-473. Date of Electronic Publication: 2023 Nov 03.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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Academic Journal

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.

Authors : Thelingwani RS; Department of DMPK/PD-BAC, African Institute of Biomedical Science & Technology (AIBST), Harare, Zimbabwe.; Dhansay K

Subjects: Cytochrome P-450 CYP1A2 Inhibitors*; Anti-Infective Agents/Anti-Infective Agents/Anti-Infective Agents/*pharmacology ; Chromones/Chromones/Chromones/*pharmacology

Source: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2012 Oct; Vol. 42 (10), pp. 989-1000. Date of Electronic Publication: 2012 Apr 25.Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited

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نتائج البحث

فلترة النتائج

Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2.

Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity in vitro .

Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes.

Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo.

CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation.

Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate.

Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver.

Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation.

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.

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