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Comparing environmental impacts of direct compaction versus wet granulation tableting methods for drugs with poor flowability by life cycle assessment.

• Authors : Hadinoto, Kunn¹ (AUTHOR) ; Tran, The-Thien¹ (AUTHOR); Chua, Angeline¹ (AUTHOR)

• Source: Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers Part A. Jul2022, Vol. 183, p439-451. 13p.

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Exploring the wet granulation growth regime map – validating the boundary between nucleation and induction.

• Authors : Wade, Jonathan B.¹ (AUTHOR) ; Miesle, James E.² (AUTHOR); Avilés, Sonia L.¹ (AUTHOR)

• Source: Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers Part A. Apr2020, Vol. 156, p469-477. 9p.

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A DEM model-based study to quantitatively compare the effect of wet and dry binder addition in high-shear wet granulation processes.

• Authors : Tamrakar, Ashutosh¹; Chen, Sheng-Wen¹; Ramachandran, Rohit¹

• Source: Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers Part A. Feb2019, Vol. 142, p307-326. 20p.

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Compartment based population balance model development of a high shear wet granulation process via dry and wet binder addition.

• Authors : Chaturbedi, Anik¹; Bandi, Chandra Kanth¹; Reddy, Dheeraj¹

• Source: Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers Part A. Jul2017, Vol. 123, p187-200. 14p.

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Microstructure of micro-crystalline cellulose based granules produced by high-shear wet granulation with long wet-massing time.

• Authors : Farber, Leon¹ ; Michaels, James N.²

• Source: Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers Part A. Apr2018, Vol. 132, p1054-1059. 6p.

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Manipulating hydrate formation during high shear wet granulation using polymeric excipients.

• Authors : Gift, Alan D.¹; Luner, Paul E.²; Luedeman, Laura³

Subjects: *METHYLXANTHINES; *DRUG granulation; *POLYMERS

• Source: Journal of Pharmaceutical Sciences. Dec2009, Vol. 98 Issue 12, p4670-4683. 14p. 7 Charts, 6 Graphs.

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A qualitative method for monitoring of nucleation and granule growth in fluid bed wet granulation by reflectance near-infrared spectroscopy.

• Authors : Weiyong Li¹ ; Cunningham, John²; Rasmussen, Henrik¹

Subjects: *NUCLEATION; *PHYSICAL & theoretical chemistry; *NEAR infrared spectroscopy

• Source: Journal of Pharmaceutical Sciences. Dec2007, Vol. 96 Issue 12, p3470-3477. 8p. 5 Graphs.

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Determination of polymorph conversion of an active pharmaceutical ingredient in wet granulation using NIR calibration models generated from the premix blends.

• Authors : Weiyong Li¹ ; Worosila, Gregory D.¹; Wang, Wayne²

Subjects: *NEAR infrared spectroscopy; *QUANTITATIVE research; *GRANULATION

• Source: Journal of Pharmaceutical Sciences. Dec2005, Vol. 94 Issue 12, p2800-2806. 7p. 1 Chart, 5 Graphs.

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Roles of granule size in over-granulation during high shear wet granulation.

• Authors : Limin Shi¹; Yushi Feng²; Changquan Calvin Sun¹

Subjects: *CYTOPLASMIC granules; *GRANULATION; *MICROCRYSTALLINE polymers

• Source: Journal of Pharmaceutical Sciences. Aug2010, Vol. 99 Issue 8, p3322-3325. 4p. 4 Graphs.

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A PAT approach to improve process understanding of high shear wet granulation through in-line particle measurement using FBRM C35.

• Authors : Jun Huang¹ ; Kaul, Goldi¹; Utz, Julia²

Subjects: *GRANULATION; *SURFACE tension; *FOULING organisms

• Source: Journal of Pharmaceutical Sciences. Jul2010, Vol. 99 Issue 7, p3205-3212. 8p.

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