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Academic Journal

Improved pharmacokinetics of AMG 517 through co-crystallization part 2: analysis of 12 carboxylic acid co-crystals.

Subjects: Benzothiazoles/Benzothiazoles/Benzothiazoles/*pharmacokinetics ; Carboxylic Acids/Carboxylic Acids/Carboxylic Acids/*pharmacokinetics ; Pyrimidines/Pyrimidines/Pyrimidines/*pharmacokinetics

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2011 Jul; Vol. 100 (7), pp. 2734-43. Date of Electronic Publication: 2011 Feb 01.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Improved pharmacokinetics of AMG 517 through co-crystallization. Part 1: comparison of two acids with corresponding amide co-crystals.

  • Authors : Stanton MK; Amgen, Inc., 360 Binney Street, Cambridge, Massachusetts 02142, USA. ; Kelly RC

Subjects: Benzothiazoles/Benzothiazoles/Benzothiazoles/*chemistry ; Benzothiazoles/Benzothiazoles/Benzothiazoles/*pharmacokinetics ; Pyrimidines/Pyrimidines/Pyrimidines/*chemistry

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2010 Sep; Vol. 99 (9), pp. 3769-78.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium:

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Academic Journal

Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption.

  • Authors : Gao P; Department of Pharmaceutics, Amgen Inc, Thousand Oaks, California 91320, USA. ; Akrami A

Subjects: Drug Carriers* ; Emulsions*; Benzothiazoles/Benzothiazoles/Benzothiazoles/*administration & dosage

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2009 Feb; Vol. 98 (2), pp. 516-28.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium:

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Academic Journal

The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics.

  • Authors : Bak A; Department of Pharmaceutics, Amgen, Inc, One Kendall Square #1000, Cambridge, Massachusetts 02139, USA. ; Gore A

Subjects: Benzothiazoles/Benzothiazoles/Benzothiazoles/*chemistry ; Pyrimidines/Pyrimidines/Pyrimidines/*chemistry ; TRPV Cation Channels/TRPV Cation Channels/TRPV Cation Channels/*antagonists & inhibitors

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 2008 Sep; Vol. 97 (9), pp. 3942-56.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium:

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