نتائج البحث

Scalable protein design using optimization in a relaxed sequence space.

• Authors : Frank, Christopher; Khoshouei, Ali; Fub, Lara

• Source: Science. 10/25/2024, Vol. 386 Issue 6720, p439-445. 7p. 5 Color Photographs.

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AI tools set off an explosion of designer proteins.

• Authors : Service RF

Subjects: Artificial Intelligence* ; Protein Engineering* ; Proteins*/Proteins*/Proteins*/chemistry

• Source: Science (New York, N.Y.) [Science] 2024 Oct 18; Vol. 386 (6719), pp. 260-261. Date of Electronic Publication: 2024 Oct 17.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Sculpting conducting nanopore size and shape through de novo protein design.

• Authors : Berhanu, Samuel^1,2; Majumder, Sagardip^1,2; Müntener, Thomas^3,4

• Source: Science. 7/19/2024, Vol. 385 Issue 6706, p282-288. 7p. 1 Color Photograph, 3 Diagrams.

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Generalized biomolecular modeling and design with RoseTTAFold All-Atom.

• Authors : Krishna R; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.

Subjects: Deep Learning* ; Proteins*/Proteins*/Proteins*/chemistry ; Protein Engineering*/Protein Engineering*/Protein Engineering*/methods

• Source: Science (New York, N.Y.) [Science] 2024 Apr 19; Vol. 384 (6693), pp. eadl2528. Date of Electronic Publication: 2024 Apr 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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De novo design of drug-binding proteins with predictable binding energy and specificity.

• Authors : Lu L; Department of Pharmaceutical Chemistry & Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.; Gou X

Subjects: Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/chemistry ; Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology ; Proteins*/Proteins*/Proteins*/chemistry

• Source: Science (New York, N.Y.) [Science] 2024 Apr 05; Vol. 384 (6691), pp. 106-112. Date of Electronic Publication: 2024 Apr 04.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Evolution-inspired engineering of nonribosomal peptide synthetases.

• Authors : Bozhüyük KAJ; Max Planck Institute for Terrestrial Microbiology, Department of Natural Products in Organismic Interactions, 35043 Marburg, Germany.; Molecular Biotechnology, Department of Biosciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.

Subjects: Peptide Synthases*/Peptide Synthases*/Peptide Synthases*/chemistry ; Peptide Synthases*/Peptide Synthases*/Peptide Synthases*/classification ; Peptide Synthases*/Peptide Synthases*/Peptide Synthases*/genetics

• Source: Science (New York, N.Y.) [Science] 2024 Mar 22; Vol. 383 (6689), pp. eadg4320. Date of Electronic Publication: 2024 Mar 22.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Protein design meets biosecurity.

• Authors : Baker D; David Baker is a professor in the Department of Biochemistry and director of the Institute for Protein Design at the University of Washington, Seattle, WA, USA.; Church G

Subjects: Artificial Intelligence* ; Biosecurity* ; Protein Engineering*

• Source: Science (New York, N.Y.) [Science] 2024 Jan 26; Vol. 383 (6681), pp. 349. Date of Electronic Publication: 2024 Jan 25.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Design of stimulus-responsive two-state hinge proteins.

• Authors : Praetorius, Florian^1,2 ; Leung, Philip J. Y.^1,2,3; Tessmer, Maxx H.⁴

• Source: Science. 8/18/2023, Vol. 381 Issue 6659, p754-760. 7p. 5 Diagrams.

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From nature to industry: Harnessing enzymes for biocatalysis.

• Authors : Buller R; Competence Center for Biocatalysis, Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences, 8820 Wädenswil, Switzerland.; Lutz S

Subjects: Biocatalysis* ; Enzymes*/Enzymes*/Enzymes*/chemistry ; Enzymes*/Enzymes*/Enzymes*/genetics

• Source: Science (New York, N.Y.) [Science] 2023 Nov 24; Vol. 382 (6673), pp. eadh8615. Date of Electronic Publication: 2023 Nov 24.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Top-down design of protein architectures with reinforcement learning.

• Authors : Lutz, Isaac D.; Wang, Shunzhi ; Norn, Christoffer

• Source: Science. 4/21/2023, Vol. 380 Issue 6642, p266-273. 8p. 5 Color Photographs.

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