نتائج البحث

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.

• Authors : Shin HR; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Initiative at the University of California, Berkeley, Berkeley, CA 94720, USA.

Subjects: Cholesterol*/Cholesterol*/Cholesterol*/metabolism ; Lysosomes*/Lysosomes*/Lysosomes*/metabolism ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism

• Source: Science (New York, N.Y.) [Science] 2022 Sep 16; Vol. 377 (6612), pp. 1290-1298. Date of Electronic Publication: 2022 Aug 25.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

تفاصيل العنوان

Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.

• Authors : Gosis BS; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Wada S

Subjects: Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism ; Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/Non-alcoholic Fatty Liver Disease*/therapy

• Source: Science (New York, N.Y.) [Science] 2022 Apr 15; Vol. 376 (6590), pp. eabf8271. Date of Electronic Publication: 2022 Apr 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

• Authors : Cangelosi AL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Subjects: Diet* ; Leucine*/Leucine*/Leucine*/metabolism ; Liver*/Liver*/Liver*/metabolism

• Source: Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. 47-56. Date of Electronic Publication: 2022 Jun 30.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Complex regulation of fatty liver disease.

• Authors : Ginsberg HN; Department of Medicine, Irving Institute for Clinical and Translational Research, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Mani A

Subjects: Lipogenesis* ; Liver*/Liver*/Liver*/metabolism ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism

• Source: Science (New York, N.Y.) [Science] 2022 Apr 15; Vol. 376 (6590), pp. 247-248. Date of Electronic Publication: 2022 Apr 14.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.

• Authors : Di Malta C; Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy.; Siciliano D

Subjects: Gene Expression Regulation, Neoplastic*; Feedback, Physiological/Feedback, Physiological/Feedback, Physiological/*physiology ; Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism

• Source: Science (New York, N.Y.) [Science] 2017 Jun 16; Vol. 356 (6343), pp. 1188-1192.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Antiaging diets: Separating fact from fiction.

• Authors : Lee MB; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195-7470, USA.; Hill CM

Subjects: Aging* ; Diet*/Diet*/Diet*/adverse effects ; Health*

• Source: Science (New York, N.Y.) [Science] 2021 Nov 19; Vol. 374 (6570), pp. eabe7365. Date of Electronic Publication: 2021 Nov 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.

• Authors : Jouandin P; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.; Marelja Z

Subjects: Fasting*; Cystine/Cystine/Cystine/*metabolism ; Drosophila Proteins/Drosophila Proteins/Drosophila Proteins/*metabolism

• Source: Science (New York, N.Y.) [Science] 2022 Feb 18; Vol. 375 (6582), pp. eabc4203. Date of Electronic Publication: 2022 Feb 18.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

• Authors : Bonah Kim; Hee Young Kim; Bo Ruem Yoon

Subjects: Arthritis; Rheumatoid* / metabolism; Glycolysis

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The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.

• Authors : Hesketh GG; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Papazotos F

Subjects: Amino Acids/Amino Acids/Amino Acids/*metabolism ; GTP Phosphohydrolases/GTP Phosphohydrolases/GTP Phosphohydrolases/*metabolism ; Lysosomes/Lysosomes/Lysosomes/*enzymology

• Source: Science (New York, N.Y.) [Science] 2020 Oct 16; Vol. 370 (6514), pp. 351-356.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

• Authors : Anandapadamanaban M; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.; Masson GR

Subjects: Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*chemistry ; Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/Mechanistic Target of Rapamycin Complex 1/*metabolism ; Monomeric GTP-Binding Proteins/Monomeric GTP-Binding Proteins/Monomeric GTP-Binding Proteins/*chemistry

• Source: Science (New York, N.Y.) [Science] 2019 Oct 11; Vol. 366 (6462), pp. 203-210.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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