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CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology

• Authors : National Institutes of Health (US); National Institute of Neurological Disorders and Stroke (US); National Institute on Aging (US)

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A perturbed network in neurodegeneration.

• Authors : Gallo, Jean-Marc¹ ; Edbauer, Dieter^2,3,4,5

• Source: Science. 10/7/2022, Vol. 378 Issue 6615, p28-29. 2p. 1 Color Photograph.

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Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.

• Authors : Kramer, Nicholas J.^1,2 (AUTHOR); Carlomagno, Yari³ (AUTHOR); Yong-Jie Zhang³ (AUTHOR)

• Source: Science. 8/12/2016, Vol. 353 Issue 6300, p708-712. 5p. 4 Graphs.

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C9orf72 is required for proper macrophage and microglial function in mice.

• Authors : O'Rourke, J. G.¹; Bogdanik, L.²; Yáñez, A.¹

• Source: Science. 3/18/2016, Vol. 351 Issue 6279, p1324-1329. 6p.

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The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS.

• Authors : Mori, Kohji¹; Shih-Ming Weng²; Arzberger, Thomas³

• Source: Science. 3/15/2013, Vol. 339 Issue 6125, p1335-1338. 4p.

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A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins

• Authors : Castelli, L.M.; Lin, Y.-H.; Sanchez-Martinez, A.

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CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology

• Authors : Ortega, Juan A.; Sasselli, Ivan R.; Boccitto, Marco ...

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