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Academic Journal

Cryo-EM reveals mechanisms of natural RNA multivalency.

  • Authors : Wang L; The State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital; The State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Center for Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Subjects: Cryoelectron Microscopy* ; RNA*/RNA*/RNA*/chemistry ; RNA*/RNA*/RNA*/ultrastructure

  • Source: Science (New York, N.Y.) [Science] 2025 May; Vol. 388 (6746), pp. 545-550. Date of Electronic Publication: 2025 Mar 13.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.

  • Authors : Liu F; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.; Wu CG

Subjects: Cryoelectron Microscopy* ; Molecular Docking Simulation* ; Parathyroid Hormone*/Parathyroid Hormone*/Parathyroid Hormone*/metabolism

  • Source: Science (New York, N.Y.) [Science] 2024 Sep 20; Vol. 385 (6715), pp. eado1868. Date of Electronic Publication: 2024 Sep 20.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Structure and inhibition of SARS-CoV-2 spike refolding in membranes.

  • Authors : Grunst MW; Department of Microbial Pathogenesis, Yale University, New Haven, CT, USA.; Qin Z

Subjects: Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/chemistry ; Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/metabolism ; Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/Spike Glycoprotein, Coronavirus*/immunology

  • Source: Science (New York, N.Y.) [Science] 2024 Aug 16; Vol. 385 (6710), pp. 757-765. Date of Electronic Publication: 2024 Aug 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Structural basis of odor sensing by insect heteromeric odorant receptors.

  • Authors : Zhao J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.; Chen AQ

Subjects: Aedes*/Aedes*/Aedes*/physiology ; Anopheles*/Anopheles*/Anopheles*/physiology ; Cryoelectron Microscopy*

  • Source: Science (New York, N.Y.) [Science] 2024 Jun 28; Vol. 384 (6703), pp. 1460-1467. Date of Electronic Publication: 2024 Jun 13.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

A neutralizing antibody prevents postfusion transition of measles virus fusion protein.

  • Authors : Zyla DS; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Della Marca R

Subjects: Antibodies, Neutralizing*/Antibodies, Neutralizing*/Antibodies, Neutralizing*/immunology ; Antibodies, Neutralizing*/Antibodies, Neutralizing*/Antibodies, Neutralizing*/chemistry ; Measles virus*/Measles virus*/Measles virus*/immunology

  • Source: Science (New York, N.Y.) [Science] 2024 Jun 28; Vol. 384 (6703), pp. eadm8693. Date of Electronic Publication: 2024 Jun 28.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Bacterial reverse transcriptase synthesizes long poly(A)-rich cDNA for antiphage defense.

  • Authors : Song XY; Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China.; Xia Y

Subjects: Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/chemistry ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/genetics ; Bacterial Proteins*/Bacterial Proteins*/Bacterial Proteins*/metabolism

  • Source: Science (New York, N.Y.) [Science] 2025 Jun 19; Vol. 388 (6753), pp. eads4639. Date of Electronic Publication: 2025 Jun 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

BRAF oncogenic mutants evade autoinhibition through a common mechanism.

  • Authors : Lavoie H; Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Université de Montréal, Montréal, QC, Canada.; Jin T

Subjects: Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/genetics ; Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/chemistry ; Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/Proto-Oncogene Proteins B-raf*/antagonists & inhibitors

  • Source: Science (New York, N.Y.) [Science] 2025 May 29; Vol. 388 (6750), pp. eadp2742. Date of Electronic Publication: 2025 May 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis.

  • Authors : Peng R; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Institute of Structural Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Subjects: RNA, Viral*/RNA, Viral*/RNA, Viral*/biosynthesis ; RNA, Viral*/RNA, Viral*/RNA, Viral*/chemistry ; Ribonucleoproteins*/Ribonucleoproteins*/Ribonucleoproteins*/chemistry

  • Source: Science (New York, N.Y.) [Science] 2025 May 15; Vol. 388 (6748), pp. eadq7597. Date of Electronic Publication: 2025 May 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis.

  • Authors : Lin H; New Cornerstone Science Laboratory, Advanced Medical Research Institute, and NHC Key Laboratory of Otorhinolaryngology, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; Department of Physiology and Pathophysiology, School of Basic Medical Sciences

Subjects: Adipocytes*/Adipocytes*/Adipocytes*/metabolism ; Adipocytes, Brown*/Adipocytes, Brown*/Adipocytes, Brown*/metabolism ; Adipocytes, Brown*/Adipocytes, Brown*/Adipocytes, Brown*/physiology

  • Source: Science (New York, N.Y.) [Science] 2025 May; Vol. 388 (6746), pp. eado4188. Date of Electronic Publication: 2025 May 01.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

RNA-mediated CRISPR-Cas13 inhibition through crRNA structural mimicry.

  • Authors : Hayes VM; Department of Microbiology, University of Washington, Seattle, WA, USA.; Zhang JT

Subjects: Bacteriophages*/Bacteriophages*/Bacteriophages*/genetics ; CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/chemistry ; CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/CRISPR-Associated Proteins*/genetics

  • Source: Science (New York, N.Y.) [Science] 2025 Apr 25; Vol. 388 (6745), pp. 387-391. Date of Electronic Publication: 2025 Apr 24.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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