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Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation

• Authors : Zenko, D; Marsh, J; Castle, AR

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GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.

• Authors : Diaz-Ortiz ME; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.

Subjects: Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/genetics ; Membrane Glycoproteins*/Membrane Glycoproteins*/Membrane Glycoproteins*/metabolism ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/genetics

• Source: Science (New York, N.Y.) [Science] 2022 Aug 19; Vol. 377 (6608), pp. eabk0637. Date of Electronic Publication: 2022 Aug 19.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

• Authors : Xiaobo Mao^1,2,3 (AUTHOR); Ou, Michael Tianhao^1,2 (AUTHOR); Karuppagounder, Senthilkumar S.^1,2,3 (AUTHOR)

• Source: Science. 9/30/2016, Vol. 353 Issue 6307, paah3374-1-aah3374-12. 12p. 6 Graphs.

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Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers.

• Authors : Fusco, Giuliana^1,2; Chen, Serene W.^1,2; Williamson, Philip T. F.³

• Source: Science. 12/15/2017, Vol. 358 Issue 6369, p1440-1443. 4p.

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α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro.

• Authors : Burré, Jacqueline¹; Sharma, Manu¹; Tsetsenis, Theodoras¹

• Source: Science. 9/24/2010, Vol. 329 Issue 5999, p1663-1667. 5p.

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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease.

• Authors : Outeiro, Tiago Fleming^1,2; Kontopoulos, Eirene³; Altmann, Stephen M.²

• Source: Science. 7/27/2007, Vol. 317 Issue 5837, p516-519. 4p. 4 Graphs.

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Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy.

• Authors : Cuervo, Ana Maria¹ ; Stefanis, Leonidas²; Fredenburg, Ross³

• Source: Science. 8/27/2004, Vol. 305 Issue 5688, p1292-1295. 4p.

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Yeast Genes That Enhance the Toxicity of a MutantHuntingtin Fragment of α-Synuclein.

• Authors : Willingham, Stephen¹; Outeiro, Tiago Fleming²; DeVit, Michael J.³

• Source: Science. 12/5/2003, Vol. 302 Issue 5651, p1769-1772. 4p. 1 Black and White Photograph, 2 Charts, 1 Graph.

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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease.

• Authors : Auluck, Pavan K.; Chan, H.Y. Edwin; Trojanowski, John Q.

• Source: Science. 2/1/2002, Vol. 295 Issue 5556, p865-868. 4p. 1 Color Photograph, 1 Chart, 2 Graphs.

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Alzheimer's and Parkinsons diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein.

• Authors : Goedert, Michel¹

• Source: Science. 8/7/2015, Vol. 349 Issue 6248, p601-5559. 10p.

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