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TheSCO2299gene fromStreptomyces coelicolorA3(2) encodes a bifunctional enzyme consisting of an RNase H domain and an acid phosphatase domain.

• Authors : Ohtani, Naoto¹ ; Saito, Natsumi¹; Tomita, Masaru¹

• Source: FEBS Journal. Jun2005, Vol. 272 Issue 11, p2828-2837. 10p.

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E. coli RNase HI and the Phosphonate-DNA/RNA Hybrid: Molecular Dynamics Simulations.

• Authors : Barvík Jr., I.¹

• Source: Nucleosides, Nucleotides & Nucleic Acids. May2005, Vol. 24 Issue 5-7, p435-441. 7p. 4 Charts.

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Direct Observation of the Three-State Folding of a Single Protein Molecule.

• Authors : Cecconi, Ciro^1,2; Shank, Elizabeth A.¹; Bustamante, Carlos^1,2,3

• Source: Science. 9/23/2005, Vol. 309 Issue 5743, p2057-2060. 4p. 1 Color Photograph, 3 Graphs.

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Structural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy.

• Authors : Sohail, Muhammad¹ ; Doran, Graeme^1,2 ; Swan Kang¹

• Source: Journal of Drug Targeting. Jan2005, Vol. 13 Issue 1, p61-70. 10p. 4 Diagrams, 1 Chart, 2 Graphs.

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Enzymatic Resolution and Base Pairing Properties of d - and l -Cyclohexenyl Nucleic Acids (CeNA).

• Authors : Ping Gu¹; Schepers, Guy¹; Griebel, Carsten²

• Source: Nucleosides, Nucleotides & Nucleic Acids. May2005, Vol. 24 Issue 5-7, p993-998. 6p. 4 Diagrams, 2 Charts.

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Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.

• Authors : Jin-Biao Ma¹; Yu-Ren Yuan¹; Meister, Gunter²

• Source: Nature. 3/31/2005, Vol. 434 Issue 7033, p666-670. 5p.

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HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.

• Authors : Fisher, Timothy S.^1,2 ; Joshi, Pheroze¹ ; Prasad, Vinayaka R.¹

• Source: AIDS Research & Therapy. 2005, Vol. 2, p8-10. 10p. 2 Diagrams, 3 Charts.

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Structure Watch.

• Source: Nature Reviews Molecular Cell Biology. Aug2005, Vol. 6 Issue 8, p597-597. 1p.

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