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An open-label study to explore the optimal design of CYP3A drug-drug interaction clinical trials in healthy Chinese people.

• Authors : Chen J; Research Ward, Beijing Friendship Hospital, Capital Medical University, Beijing, China.; Li J

Subjects: Drug Interactions* ; Midazolam*/Midazolam*/Midazolam*/pharmacokinetics ; Midazolam*/Midazolam*/Midazolam*/administration & dosage

• Source: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Aug; Vol. 12 (4), pp. e1252.Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States

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Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin.

• Authors : Hohmann N; Department of Clinical Pharmacology and Pharmacoepidemiology, Internal Medicine IX, Medical Faculty of Heidelberg, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.; Friedrichs AS

Subjects: Rifampin*/Rifampin*/Rifampin*/administration & dosage ; Rifampin*/Rifampin*/Rifampin*/pharmacology ; Hypericum*/Hypericum*/Hypericum*/chemistry

• Source: Clinical and translational science [Clin Transl Sci] 2024 Aug; Vol. 17 (8), pp. e70007.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping.

• Authors : Oda, Ayako¹ (AUTHOR); Suzuki, Yosuke¹ (AUTHOR) y‐suzuki@my‐pharm.ac.jp; Sato, Haruki¹ (AUTHOR)

• Source: CTS: Clinical & Translational Science. Mar2024, Vol. 17 Issue 3, p1-11. 11p.

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Clinical assessment of momelotinib drug-drug interactions via CYP3A metabolism and transporters.

• Authors : Ho YL; GSK, Collegeville, Pennsylvania, USA.; Gorycki P

Subjects: Ritonavir* ; Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Benzamides*

• Source: Clinical and translational science [Clin Transl Sci] 2024 Apr; Vol. 17 (4), pp. e13799.Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN:

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A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions.

• Authors : Kovar C; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.

Subjects: Dasatinib*/Dasatinib*/Dasatinib*/pharmacokinetics ; Dasatinib*/Dasatinib*/Dasatinib*/administration & dosage ; Dasatinib*/Dasatinib*/Dasatinib*/pharmacology

• Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jul; Vol. 13 (7), pp. 1144-1159. Date of Electronic Publication: 2024 May 01.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats.

• Authors : Fukuno, Shuhei¹ (AUTHOR); Nagai, Katsuhito¹ (AUTHOR); Kurotobi, Akemi¹ (AUTHOR)

• Source: Xenobiotica. May2023, Vol. 53 Issue 5, p421-428. 8p.

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Tiered approach to evaluate the CYP3A victim and perpetrator drug-drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling.

• Authors : Mulford DJ; Phathom Pharmaceuticals, Inc., Buffalo Grove, Illinois, USA.; Ramsden D

Subjects: Cytochrome P-450 CYP3A Inhibitors*/Cytochrome P-450 CYP3A Inhibitors*/Cytochrome P-450 CYP3A Inhibitors*/pharmacokinetics ; Cytochrome P-450 CYP3A Inducers*/Cytochrome P-450 CYP3A Inducers*/Cytochrome P-450 CYP3A Inducers*/pharmacokinetics; Humans

• Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Apr; Vol. 12 (4), pp. 532-544. Date of Electronic Publication: 2023 Mar 10.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Effects of CYP3A Inhibition, CYP3A Induction, and Gastric Acid Reduction on the Pharmacokinetics of Ripretinib, a Switch Control KIT Tyrosine Kinase Inhibitor.

• Authors : Li, Xiaoyan¹ (AUTHOR) ; Shelton, Mark J² (AUTHOR); Wang, Jing¹ (AUTHOR)

• Source: Clinical Pharmacology in Drug Development. Oct2022, Vol. 11 Issue 10, p1165-1176. 12p.

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A phase 1, open-label, randomized drug–drug interaction study of zanubrutinib with moderate or strong CYP3A inhibitors in patients with B-cell malignancies.

• Authors : Tariq, Bilal¹ (AUTHOR); Ou, Ying C.² (AUTHOR); Stern, Jennifer C.² (AUTHOR)

• Source: Leukemia & Lymphoma. Feb2023, Vol. 64 Issue 2, p329-338. 10p.

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Physiologically-based pharmacokinetic modeling for primary metabolites of CYP3A and P-glycoprotein inhibitors in drug-drug interactions: Should we assume the free drug hypothesis?

• Authors : Yamazaki S; Drug Metabolism & Pharmacokinetics, Janssen Research & Development, LLC, San Diego, California, USA.; Evers R

Subjects: Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/Cytochrome P-450 CYP3A*/metabolism ; Cytochrome P-450 CYP3A Inhibitors*/Cytochrome P-450 CYP3A Inhibitors*/Cytochrome P-450 CYP3A Inhibitors*/pharmacokinetics; Humans

• Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Jan; Vol. 12 (1), pp. 8-12. Date of Electronic Publication: 2022 Nov 11.Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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