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Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietAgeing is a universal, multifactorial phenomenon, determined by genetic and environmental factors such as diet, stress etc. Diet associated disorders are widely prevalent in India and have been attracting much attention and research in recent times, mostly due to increased awareness among population of the importance of nutrition and balanced diet. Adaptation of western lifestyle (eg. consupmtion of calorie rich, high fat foods, lack of physical activity etc) has increased the prevalence of metabolic disorders like obesity, hypertension, Type 2 Diabetes, cardiovascular diseases etc. It is known that obesity and diabetes per se accelerate ageing, but it is not clear whether or not superimposing diabetes on obesity accelerates ageing. We tested the hypothesis that superimposing Type 2 Diabetes/aggravated insulin resistance on obesity accelerates ageing, by chronic feeding of high sucrose diet (HSD) to WNIN/Gr-Ob, the obese mutant rats of NIN, which aggravated insulin resistance significantly in these obese rats. The survival analysis by Kaplan Meier plot showed decreased longevity in HSD fed rats compared to controls fed starch based diet and in line, cumulative hazard was also higher in HSD fed rats than controls. While the finding that the total DNA damage, an important ageing marker, was significantly higher in HSD fed than control rats appears to confirm the reduced longevity / accelerated ageing in them, the significantly lower telomere length in the liver and brain of HSD fed rats than their age and sex matched control rats fed starch based diet, after 6 months on their respective diets appears to unequivocally demonstrate the accelerated ageing / decreased longevity in HSD fed WNIN/Gr-Ob rats. Our results support the hypothesis that aggravating insulin resistance in obese rats through high sucrose feeding decreases longevity / accelerate aging.Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose DietIncreased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet Submit Manuscript | http://medcraveonline.com Abbreviations: HSD: High Sucrose Diet, SBD: Starch Based Diet, WNIN/Gr-Ob: Wistar National Institute of Nutrition Obese rats, HOMA IR: Homeostatic model assessment Insulin Resistance, AUC: Area Under Curve, OGTT: Oral Glucose Tolerance Test, ROS: Reactive Oxygen Species. Introduction Ageing is a universal phenomenon, defined as the process of gradual and

• Authors : Aruna Potukuchi; Uma Addepally; and Raghunath Manchala

Subjects: High sucrose diet; Type 2 Diabetes; Ageing

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Catastrophic Expense & Financial Protection Mechanisms to Achieve Universal Health Coverage: A Review

• Authors : Arun K Aggarwal*

Subjects: Global community; Financial protection; Catastrophic

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Revisiting Kant's Universal Law and Humanity Formulas

• Authors : Govedarica, Jelena

• Source: Filozofija i društvo

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Mercedes de vega Armijo [coord.], La búsqueda perpetua: lo propio y lo universal de la cultura latinoamericana, vol. III. La Literatura hispanoamericana, México, SRE-Dirección General del Acervo Histórico Diplomático, 2011, 295 pp.

• Authors : Rodrigo Hernández Vera

Subjects: Multidisciplinarias (Ciencias Sociales)

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'FISCHER, Manuela, BOLZ, Peter, KAMEL, Susan, Adolf Bastian and His Universal Archive of Humanity, The Origins of German Anthropology'

• Authors : Georget, Jean-Louis

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Resource sharing: new technologies as a must for universal availability of information: 16th International Essen Symposium, 18 October-21 October 1993: Festschrift in honor of Hans-Peter Geh, edited by Ahmed H. Helal, Joachim W. Weiss

• Authors : Scolari, Antonio

• Source: Bollettino AIB (1992-2012); Vol. 36 No. 2 (1996); p. 200-201 ; Bollettino AIB (1992-2011); V. 36 N. 2 (1996): Giugno; p. 200-201 ; 2239-6144 ; 1121-1490

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UNIMARC/Authorities: universal format for authorities

• Authors : Dini, Rossella

• Source: Bollettino AIB (1992-2012); Vol. 33 No. 1 (1993): Marzo; p. 98-100 ; Bollettino AIB (1992-2011); V. 33 N. 1 (1993): Marzo; p. 98-100 ; 2239-6144 ; 1121-1490

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Reseña de 'Historia universal del Estado. Desde la sociedad preestatal hasta el Estado de la sociedad industrial' de Marquardt, Bernd

Subjects: Relaciones Internacionales

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Systemic solutions for addressing non-communicable diseases in low-and middle-income countries

• Authors : Ganju, A.; Goulart, A.C.; Ray, A. ...

Subjects: Low-and middle-income countries; Multisectoral; Non-communicable diseases

• Source: Scopus OA2020

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European Refugee Crisis: Where do Public Intellectuals Stand?

• Authors : Pilar Damião de Medeiros

Subjects: European refugee crisis; Public intellectuals; Public debate

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