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Publication : xenobiotica

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Academic Journal

Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism.

Authors : Li, Run¹ (AUTHOR); Wang, Qingqing¹ (AUTHOR); Liu, Zihou¹ (AUTHOR)

Source: Xenobiotica. Mar2023, Vol. 53 Issue 3, p184-192. 9p.

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Academic Journal

Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats.

Authors : Fukuno, Shuhei¹ (AUTHOR); Nagai, Katsuhito¹ (AUTHOR); Kurotobi, Akemi¹ (AUTHOR)

Source: Xenobiotica. May2023, Vol. 53 Issue 5, p421-428. 8p.

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Academic Journal

Characterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1′-OH and 4-OH midazolam.

Authors : Olsen, Line Rørbæk¹ (AUTHOR) ; Gabel-Jensen, Charlotte¹ (AUTHOR); Wubshet, Sileshi Gizachew² (AUTHOR)

Source: Xenobiotica. Feb2016, Vol. 46 Issue 2, p99-107. 9p.

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Academic Journal

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.

Authors : Samuelsson, Kristin¹ (AUTHOR); Pickup, Kathryn¹ (AUTHOR); Sarda, Sunil¹ (AUTHOR)

Source: Xenobiotica. Nov2012, Vol. 42 Issue 11, p1128-1137. 10p.

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Academic Journal

Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats.

Authors : Vuppugalla, Ragini¹ (AUTHOR) ; Zhang, Yueping¹ (AUTHOR); Chang, Shu² (AUTHOR)

Source: Xenobiotica. Nov2012, Vol. 42 Issue 11, p1058-1068. 11p.

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Academic Journal

Effects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure.

Authors : Doi, Masami¹ (AUTHOR); Kajikawa, Noriko¹ (AUTHOR); Aiba, Tetsuya¹ (AUTHOR)

Source: Xenobiotica. May2020, Vol. 50 Issue 5, p506-514. 9p.

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Academic Journal

Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1'-hydroxylation.

Authors : Emoto, C.¹ (AUTHOR); Iwasaki, K.¹ (AUTHOR)

Source: Xenobiotica. Jun2007, Vol. 37 Issue 6, p592-603. 12p. 4 Charts, 3 Graphs.

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Marked species differences in the bioavailability of midazolam in cynomolgus monkeys and humans.

Authors : Sakuda, S.¹ (AUTHOR) ; Akabane, T.¹ (AUTHOR); Teramura, T.¹ (AUTHOR)

Source: Xenobiotica. Apr2006, Vol. 36 Issue 4, p331-340. 10p. 5 Charts, 5 Graphs.

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Academic Journal

Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam.

Authors : Kuze, J.¹ (AUTHOR); Mutoh, T.¹ (AUTHOR); Takenaka, T.¹ (AUTHOR)

Source: Xenobiotica. Jul2013, Vol. 43 Issue 7, p598-606. 9p.

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Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats.

Authors : Kanazu, Takushi¹ ; Okamura, Noboru^1,2; Yamaguchi, Yoshitaka¹

Source: Xenobiotica. Apr2005, Vol. 35 Issue 4, p305-317. 13p.

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فلترة النتائج

Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism.

Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats.

Characterization of midazolam metabolism in locusts: the role of a CYP3A4-like enzyme in the formation of 1′-OH and 4-OH midazolam.

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers.

Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats.

Effects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure.

Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1'-hydroxylation.

Marked species differences in the bioavailability of midazolam in cynomolgus monkeys and humans.

Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam.

Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug–drug interaction model rats.

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