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  • 1-10 ل  62 نتائج ل ""CHECKPOINT kinase 1""

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Academic Journal

Exosomes derived from hUC-MSCs exhibit ameliorative efficacy upon previous cesarean scar defect via orchestrating β-TrCP/CHK1 axis.

  • Authors : Zeng X; Department of Obstetrics, Guizhou Provincial People's Hospital, Guiyang, 550001, Guizhou, China.; Liao Y

Subjects: Exosomes*/Exosomes*/Exosomes*/metabolism ; Checkpoint Kinase 1*/Checkpoint Kinase 1*/Checkpoint Kinase 1*/metabolism ; Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/metabolism

  • Source: Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 489. Date of Electronic Publication: 2025 Jan 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Inhibition of checkpoint kinase 1 potentiates anticancer activity of gemcitabine in bladder cancer cells.

  • Authors : Isono M; Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan. .; Okubo K

Subjects: Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/Antimetabolites, Antineoplastic/*pharmacology ; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology ; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2021 May 13; Vol. 11 (1), pp. 10181. Date of Electronic Publication: 2021 May 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Gynecologic Cancer InterGroup CA125 response has a high negative predictive value for CHK1 inhibitor RECIST response in recurrent ovarian cancer.

  • Authors : Ibanez KR; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 6B12, Bethesda, MD, 20892, USA.; Donohue D

Subjects: CA-125 Antigen*/CA-125 Antigen*/CA-125 Antigen*/blood ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/drug therapy ; Ovarian Neoplasms*/Ovarian Neoplasms*/Ovarian Neoplasms*/blood

  • Source: Scientific reports [Sci Rep] 2024 Jul 29; Vol. 14 (1), pp. 17459. Date of Electronic Publication: 2024 Jul 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Fms-like tyrosine kinase 3-internal tandem duplications epigenetically activates checkpoint kinase 1 in acute myeloid leukemia cells

Subjects: Adult; Male; Chromatin Immunoprecipitation

  • Source: Sci RepScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

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Academic Journal

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

  • Authors : Naeem W; Institute of Basic Medical Sciences, Khyber Medical University, Phase V, Peshawar, 25000, Pakistan.; Nawab F

Subjects: DNA Repair*/DNA Repair*/DNA Repair*/genetics ; Mutation* ; Mouth Neoplasms*/Mouth Neoplasms*/Mouth Neoplasms*/genetics

  • Source: Scientific reports [Sci Rep] 2025 Mar 06; Vol. 15 (1), pp. 7896. Date of Electronic Publication: 2025 Mar 06.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers.

  • Authors : Moens S; VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.

Subjects: Carboplatin/Carboplatin/Carboplatin/*pharmacology ; Cell Cycle Checkpoints/Cell Cycle Checkpoints/Cell Cycle Checkpoints/*drug effects ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*genetics

  • Source: Scientific reports [Sci Rep] 2021 Feb 04; Vol. 11 (1), pp. 3176. Date of Electronic Publication: 2021 Feb 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation.

  • Authors : Gong EY; Unidad de Investigación, Hospital Universitario de Canarias, Ofra s/n, La Cuesta, La Laguna, 38320, Tenerife, Spain.; Nano-Bio Resources Center, Sookmyung Women's University, Chungpa-Dong 2-Ka, Yongsan-ku, Seoul, 04310, Republic of Korea.

Subjects: G2 Phase Cell Cycle Checkpoints* ; Proteolysis*; Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*metabolism

  • Source: Scientific reports [Sci Rep] 2018 Dec 03; Vol. 8 (1), pp. 17536. Date of Electronic Publication: 2018 Dec 03.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.

  • Authors : Gill MR; CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.; Harun SN

Subjects: Checkpoint Kinase 1/Checkpoint Kinase 1/Checkpoint Kinase 1/*metabolism ; Coordination Complexes/Coordination Complexes/Coordination Complexes/*chemistry ; DNA Replication/DNA Replication/DNA Replication/*drug effects

  • Source: Scientific reports [Sci Rep] 2016 Aug 25; Vol. 6, pp. 31973. Date of Electronic Publication: 2016 Aug 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis and new DNA targeting activity of 6- and 7-tert-butylfascaplysins

Subjects: Male; Marine compound; Indoles

  • Source: Sci RepScientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

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Academic Journal

CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response.

  • Authors : Bargiela-Iparraguirre J; Dpto.Bioquímica. Fac. Medicina. Instituto de Investigaciones Biomédicas Madrid CSIC-UAM; Madrid, Spain.

Subjects: Chemoradiotherapy* ; Gene Expression Regulation, Enzymologic*/Gene Expression Regulation, Enzymologic*/Gene Expression Regulation, Enzymologic*/drug effects ; Gene Expression Regulation, Enzymologic*/Gene Expression Regulation, Enzymologic*/Gene Expression Regulation, Enzymologic*/radiation effects

  • Source: Scientific reports [Sci Rep] 2016 Feb 12; Vol. 6, pp. 21519. Date of Electronic Publication: 2016 Feb 12.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 ل  62 نتائج ل ""CHECKPOINT kinase 1""