نتائج البحث

N-terminal degradation activates the NLRP1B inflammasome.

• Authors : Chui, Ashley J. (AUTHOR); Okondo, Marian C. (AUTHOR); Rao, Sahana D. (AUTHOR)

• Source: Science. 4/5/2019, Vol. 364 Issue 6435, p82-85. 4p. 4 Diagrams.

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Human STING is a proton channel.

• Authors : Liu, Bingxu^1,2,3 ; Carlson, Rebecca J.^1,4; Pires, Ivan S.³

• Source: Science. 8/4/2023, Vol. 381 Issue 6657, p508-514. 7p. 4 Color Photographs.

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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

• Authors : Orecchioni, Marco; Kobiyama, Kouji; Winkels, Holger

Subjects: Atherosclerosis; Cardiovascular; Neurosciences

• Source: Science. 375(6577)

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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

• Authors : Bo Hu¹ (AUTHOR); Chengcheng Jin¹ (AUTHOR); Hua-Bing Li¹ (AUTHOR)

• Source: Science. 11/11/2016, Vol. 354 Issue 6313, p765-768. 4p. 1 Color Photograph, 3 Graphs.

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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells.

• Authors : Arbore, Giuseppina¹; West, Erin E.²; Spolski, Rosanne²

• Source: Science. 6/17/2016, Vol. 352 Issue 6292, p1424-aad1210-11. 12p.

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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

• Authors : Liman Zhang^1,2; Shuobing Chen^3,4; Jianbin Ruan^1,2

• Source: Science. 10/23/2015, Vol. 350 Issue 1659, p404-409. 6p.

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Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

• Authors : Sandstrom, Andrew; Mitchell, Patrick S; Goers, Lisa

Subjects: Biodefense; Infectious Diseases; Emerging Infectious Diseases

• Source: Science. 364(6435)

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Bacterial gasdermins reveal an ancient mechanism of cell death.

• Authors : Johnson, Alex G.; Wein, Tanita; Mayer, Megan L.

• Source: Science. 1/14/2022, Vol. 375 Issue 6577, p221-225. 5p. 4 Diagrams.

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The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

• Authors : Tenthorey, Jeannette L; Haloupek, Nicole; López-Blanco, José Ramón

Subjects: Vaccine Related; Prevention; Emerging Infectious Diseases

• Source: Science. 358(6365)

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Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.

• Authors : Robinson, Kim S.; Teo, Daniel Eng Thiam; Tan, Kai Sen

• Source: Science. 12/4/2020, Vol. 370 Issue 6521, p1182-1182. 1p. 1 Diagram.

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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.

• Authors : Magupalli, Venkat Giri ; Negro, Roberto ; Yuzi Tian

• Source: Science. 9/18/2020, Vol. 369 Issue 6510, p1448-1448. 1p. 1 Diagram.

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Assembling the wheel of death.

• Authors : Zhonghua Liu¹; Tsan Sam Xiao¹

• Source: Science. 10/23/2015, Vol. 350 Issue 1659, p376-377. 2p.

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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death.

• Authors : Orning, Pontus (AUTHOR); Weng, Dan (AUTHOR); Starheim, Kristian (AUTHOR)

Subjects: PATHOGENIC microorganisms; CASPASES; CELL death

• Source: Science. 11/30/2018, Vol. 362 Issue 6418, p1064-1069. 6p. 2 Diagrams, 2 Graphs.

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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

• Authors : Marco Orecchioni; Kouji Kobiyama; Holger Winkels

Subjects: Adult; Aging; Inflammasomes

• Source: Science (New York, N.Y.), vol 375, iss 6577

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Inflammasomes take the wheel.

• Authors : K. L. M.

• Source: Science. 10/23/2015, Vol. 350 Issue 1659, p394-394. 1/8p.

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Dying cells fan the flames of inflammation

• Authors : Kim Newton; Nobuhiko Kayagaki; Vishva M. Dixit

Subjects: Programmed cell death; Inflammasomes; Cell Adhesion Molecules, Neuronal

• Source: Science. 374:1076-1080

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RESEARCH.

• Authors : P. J. H. (AUTHOR); P. A. K. (AUTHOR); B. G. (AUTHOR)

• Source: Science. 9/15/2017, Vol. 357 Issue 6356, p1108-1110. 3p. 4 Color Photographs, 1 Black and White Photograph.

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The scent of atherosclerosis.

• Authors : Rayner, Katey J.; Rasheed, Adil

Subjects: OLFACTORY receptors; ATHEROSCLEROTIC plaque; ATHEROSCLEROSIS

• Source: Science. 1/14/2022, Vol. 375 Issue 6577, p145-146. 2p. 1 Color Photograph.

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Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.

• Authors : Palaferri Schieber, Alexandria M.; Lee, Yujung Michelle; Chang, Max W.

Subjects: ESCHERICHIA coli; BIOCOMPATIBILITY; ESCHERICHIA coli diseases

• Source: Science. 10/30/2015, Vol. 350 Issue 6260, p558-563. 6p.

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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

• Authors : Dror S. Shouval; Ruslan Medzhitov; Scott B. Snapper

Subjects: 0301 basic medicine; Inflammasomes; medicine.medical_treatment

• Source: Science. 356:513-519

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Rescue from a fiery death: A therapeutic endeavor: Inhibiting cell death by pyroptosis could limit inflammatory diseases and cancer.

• Authors : Nobuhiko Kayagaki; Dixit, Vishva M.

Subjects: CELL death inhibition; CANCER; INTERLEUKIN-1

• Source: Science. 11/8/2019, Vol. 366 Issue 6466, p688-689. 2p. 1 Diagram.

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Regulatory evolution of innate immunity through co-option of endogenous retroviruses

• Authors : Edward B. Chuong; Cédric Feschotte; Nels C. Elde

Subjects: 0301 basic medicine; Inflammasomes; Endogenous retrovirus

• Source: Science. 351:1083-1087

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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

• Authors : Xinzheng Zhang; Alexander B. Tong; Jiayi Wu

Subjects: CARD Signaling Adaptor Proteins; Inflammasomes; Protein subunit

• Source: Science. 350:404-409

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Immunotherapy for neurodegeneration?

• Authors : Liu, Yingjun; Aguzzi, Adriano

Subjects: NEURODEGENERATION; IMMUNOTHERAPY; APOPTOSIS

• Source: Science. 4/12/2019, Vol. 364 Issue 6436, p130-131. 2p. 1 Color Photograph.

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Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

• Authors : David R. Hinton; Shoba Amarnath; Takeshi Mizutani

Subjects: RM; Inflammasomes; Caspase 1

• Source: Science. 346:1000-1003

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