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Academic Journal

The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice.

  • Authors : Ben Abdallah H; Department of Dermatology, Aarhus University Hospital, Aarhus N, Denmark.; Marino G

Subjects: HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/metabolism ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/drug effects

  • Source: PloS one [PLoS One] 2024 Sep 26; Vol. 19 (9), pp. e0310915. Date of Electronic Publication: 2024 Sep 26 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.

  • Authors : Mrozek EM; Cancer Genetics Lab, Pulmonary Medicine Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Bajaj V

Subjects: HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*antagonists & inhibitors ; Neoplasms/Neoplasms/Neoplasms/*drug therapy ; TOR Serine-Threonine Kinases/TOR Serine-Threonine Kinases/TOR Serine-Threonine Kinases/*antagonists & inhibitors

  • Source: PloS one [PLoS One] 2021 Apr 23; Vol. 16 (4), pp. e0248380. Date of Electronic Publication: 2021 Apr 23 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer.

  • Authors : Le B; Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Powers GL

Subjects: Micelles* ; Phosphoinositide-3 Kinase Inhibitors*; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*pharmacology

  • Source: PloS one [PLoS One] 2017 Mar 28; Vol. 12 (3), pp. e0174658. Date of Electronic Publication: 2017 Mar 28 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.

  • Authors : Prince TL; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.; Kijima T

Subjects: Mutation*; Benzoquinones/Benzoquinones/Benzoquinones/*pharmacology ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*chemistry

  • Source: PloS one [PLoS One] 2015 Oct 30; Vol. 10 (10), pp. e0141786. Date of Electronic Publication: 2015 Oct 30 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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