نتائج البحث

A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity.

• Authors : Alami N; AbbVie, North Chicago, Illinois, United States of America.; Pfizer, Chicago, Illinois, United States of America.

Subjects: Wolbachia* ; Onchocerciasis*; Adult

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Jul 10; Vol. 17 (7), pp. e0011392. Date of Electronic Publication: 2023 Jul 10 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

• Authors : von Geldern TW; Global Pharmaceutical Research and Development, AbbVie, North Chicago, Illinois, United States of America.; Franciscan Institute for World Health, Franciscan University, Steubenville, Ohio, United States of America.

Subjects: Drug Discovery*; Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*pharmacology ; Filaricides/Filaricides/Filaricides/*pharmacology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Feb 28; Vol. 13 (2), pp. e0007159. Date of Electronic Publication: 2019 Feb 28 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

[Untitled]

Subjects: Doxycycline; Drug discovery; Public Health, Environmental and Occupational Health

• Source: PLOS Neglected Tropical Diseases.

تفاصيل العنوان

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

• Authors : Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Germany.; Koschel M

Subjects: Anti-Bacterial Agents/Anti-Bacterial Agents/Anti-Bacterial Agents/*pharmacology ; Filarioidea/Filarioidea/Filarioidea/*microbiology ; Microfilariae/Microfilariae/Microfilariae/*microbiology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Aug 05; Vol. 13 (8), pp. e0007636. Date of Electronic Publication: 2019 Aug 05 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان