نتائج البحث

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding.

• Authors : Perlinska, Agata P.¹ (AUTHOR); Stasiulewicz, Adam^1,2 (AUTHOR); Nguyen, Mai Lan^1,3 (AUTHOR)

• Source: PLoS Computational Biology. 11/21/2022, Vol. 18 Issue 11, p1-22. 22p. 3 Diagrams, 2 Charts, 1 Graph.

تفاصيل العنوان

Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity.

• Authors : Barsi S; Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary.; Papp H

Subjects: SARS-CoV-2* ; COVID-19 Drug Treatment*; Antiviral Agents/Antiviral Agents/Antiviral Agents/pharmacology

• Source: PLoS computational biology [PLoS Comput Biol] 2022 Apr 11; Vol. 18 (4), pp. e1010021. Date of Electronic Publication: 2022 Apr 11 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity.

• Authors : Szilvia Barsi; Henrietta Papp; Alberto Valdeolivas

Subjects: Biology (General); QH301-705.5

• Source: PLoS Computational Biology, Vol 18, Iss 4, p e1010021 (2022)

تفاصيل العنوان

In silico prediction of HIV-1-host molecular interactions and their directionality.

• Authors : Chai, Haiting¹ (AUTHOR); Gu, Quan¹ (AUTHOR); Hughes, Joseph¹ (AUTHOR)

• Source: PLoS Computational Biology. 2/8/2022, Vol. 18 Issue 2, p1-26. 26p. 1 Color Photograph, 5 Charts, 4 Graphs.

تفاصيل العنوان

Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of action.

• Authors : Czuppon, Peter^1,2 (AUTHOR) ; Débarre, Florence¹ (AUTHOR); Gonçalves, Antonio³ (AUTHOR)

• Source: PLoS Computational Biology. 3/1/2021, Vol. 17 Issue 3, p1-19. 19p. 3 Charts, 4 Graphs.

تفاصيل العنوان

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.

• Authors : Sego TJ; Department of Intelligent Systems Engineering, Indiana University, Bloomington, Indiana, United States of America.; Biocomplexity Institute, Indiana University, Bloomington, Indiana, United States of America.

Subjects: Epithelium*/Epithelium*/Epithelium*/immunology ; Epithelium*/Epithelium*/Epithelium*/virology ; Models, Immunological*

• Source: PLoS computational biology [PLoS Comput Biol] 2020 Dec 21; Vol. 16 (12), pp. e1008451. Date of Electronic Publication: 2020 Dec 21 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.

• Authors : T J Sego; Josua O Aponte-Serrano; Juliano Ferrari Gianlupi

Subjects: Biology (General); QH301-705.5

• Source: PLoS Computational Biology, Vol 16, Iss 12, p e1008451 (2020)

تفاصيل العنوان

Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition

• Authors : Daniel Coombs; Soren Gantt; Catherine M. Byrne

Subjects: 0301 basic medicine; RNA viruses; CD4-Positive T-Lymphocytes

• Source: PLoS Computational BiologyPLoS Computational Biology, Vol 14, Iss 4, p e1006129 (2018)

تفاصيل العنوان

Life cycle synchronization is a viral drug resistance mechanism.

• Authors : Neagu IA; Program for Evolutionary Dynamics, Department of Mathematics and Department of Organismic & Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America.; Department of Physics, Harvard University, Cambridge, Massachusetts, United States of America.

Subjects: Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Drug Resistance, Viral/Drug Resistance, Viral/Drug Resistance, Viral/*genetics ; HIV Infections/HIV Infections/HIV Infections/*drug therapy

• Source: PLoS computational biology [PLoS Comput Biol] 2018 Feb 15; Vol. 14 (2), pp. e1005947. Date of Electronic Publication: 2018 Feb 15 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Life cycle synchronization is a viral drug resistance mechanism.

• Authors : Iulia A Neagu; Jason Olejarz; Mark Freeman

Subjects: Biology (General); QH301-705.5

• Source: PLoS Computational Biology, Vol 14, Iss 2, p e1005947 (2018)

تفاصيل العنوان