نتائج البحث

Discovery of novel dual adenosine A1/A2A receptor antagonists using deep learning, pharmacophore modeling and molecular docking.

• Authors : Wang M; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.; Hou S

Subjects: Adenosine A1 Receptor Antagonists* ; Adenosine A2 Receptor Antagonists* ; Deep Learning*

• Source: PLoS computational biology [PLoS Comput Biol] 2021 Mar 19; Vol. 17 (3), pp. e1008821. Date of Electronic Publication: 2021 Mar 19 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions.

• Authors : Bruzzese A; Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain.; Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Subjects: Adenosine A2 Receptor Agonists*/Adenosine A2 Receptor Agonists*/Adenosine A2 Receptor Agonists*/chemistry ; Adenosine A2 Receptor Agonists*/Adenosine A2 Receptor Agonists*/Adenosine A2 Receptor Agonists*/metabolism ; Phospholipids*/Phospholipids*/Phospholipids*/chemistry

• Source: PLoS computational biology [PLoS Comput Biol] 2020 Apr 16; Vol. 16 (4), pp. e1007818. Date of Electronic Publication: 2020 Apr 16 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions.

• Authors : Rahmaninejad, Hadi¹ (AUTHOR) ; Pace, Tom¹ (AUTHOR) ; Bhatt, Shashank² (AUTHOR)

• Source: PLoS Computational Biology. 6/25/2020, Vol. 16 Issue 6, p1-31. 31p. 3 Diagrams, 3 Charts, 7 Graphs.

تفاصيل العنوان

Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations.

• Authors : Jespers W; Department of Cell and Molecular Biology, Uppsala University, Biomedical Center (BMC), Uppsala, Sweden.; Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.

Subjects: Receptor, Adenosine A2A/Receptor, Adenosine A2A/Receptor, Adenosine A2A/*chemistry; Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/chemistry ; Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/pharmacology

• Source: PLoS computational biology [PLoS Comput Biol] 2021 Nov 24; Vol. 17 (11), pp. e1009152. Date of Electronic Publication: 2021 Nov 24 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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A novel kinetic model to demonstrate the independent effects of ATP and ADP/Pi concentrations on sarcomere function.

• Authors : Schmidt AA; Department of Biomedical Engineering, University of California, Irvine, Irvine, California, United States of America.; UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), University of California, Irvine, Irvine, California, United States of America.

Subjects: Adenosine Diphosphate*/Adenosine Diphosphate*/Adenosine Diphosphate*/metabolism ; Sarcomeres*/Sarcomeres*/Sarcomeres*/physiology ; Sarcomeres*/Sarcomeres*/Sarcomeres*/metabolism

• Source: PLoS computational biology [PLoS Comput Biol] 2024 Aug 05; Vol. 20 (8), pp. e1012321. Date of Electronic Publication: 2024 Aug 05 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Chemophoresis engine: A general mechanism of ATPase-driven cargo transport.

• Authors : Sugawara T; Universal Biology Institute, The University of Tokyo, Tokyo, Japan.; Kaneko K

Subjects: Adenosine Triphosphatases*/Adenosine Triphosphatases*/Adenosine Triphosphatases*/metabolism ; Organelles*/Organelles*/Organelles*/metabolism; Adenosine Triphosphate/Adenosine Triphosphate/Adenosine Triphosphate/metabolism

• Source: PLoS computational biology [PLoS Comput Biol] 2022 Jul 25; Vol. 18 (7), pp. e1010324. Date of Electronic Publication: 2022 Jul 25 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Investigating the structural changes due to adenosine methylation of the Kaposi's sarcoma-associated herpes virus ORF50 transcript.

• Authors : Röder K; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.; Barker AM

Subjects: Herpesvirus 8, Human*/Herpesvirus 8, Human*/Herpesvirus 8, Human*/genetics ; Herpesvirus 8, Human*/Herpesvirus 8, Human*/Herpesvirus 8, Human*/metabolism ; Sarcoma, Kaposi*/Sarcoma, Kaposi*/Sarcoma, Kaposi*/genetics

• Source: PLoS computational biology [PLoS Comput Biol] 2022 May 26; Vol. 18 (5), pp. e1010150. Date of Electronic Publication: 2022 May 26 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery.

• Authors : Phillips, Andrew J. K.¹ ; Klerman, Elizabeth B.¹; Butler, James P.^2,3

• Source: PLoS Computational Biology. 10/26/2017, Vol. 13 Issue 10, p1-21. 21p.

تفاصيل العنوان

Communication over the network of binary switches regulates the activation of A2A adenosine receptor.

• Authors : Lee Y; National Leading Research Laboratory (NLRL) of Molecular Modeling and Drug Design, College of Pharmacy, Graduate School of Pharmaceutical Sciences, and Global Top 5 Research Program, Ewha Womans University, Seoul 120-750, Korea.; Choi S

Subjects: Molecular Dynamics Simulation*; Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/Adenosine A2 Receptor Agonists/*metabolism ; Adenosine A2 Receptor Antagonists/Adenosine A2 Receptor Antagonists/Adenosine A2 Receptor Antagonists/*metabolism

• Source: PLoS computational biology [PLoS Comput Biol] 2015 Feb 09; Vol. 11 (2), pp. e1004044. Date of Electronic Publication: 2015 Feb 09 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

تفاصيل العنوان

Dynamic recycling of extracellular ATP in human epithelial intestinal cells.

• Authors : Saffioti NA; Instituto de Química y Físico-Química Biológicas 'Prof. Alejandro C. Paladini', Universidad de Buenos Aires (UBA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.; Universidad de Buenos Aires (UBA), Facultad de Farmacia y Bioquímica, Departamento de Química Biológica, Cátedra de Química Biológica, Buenos Aires, Argentina.

Subjects: Adenosine Triphosphate*/Adenosine Triphosphate*/Adenosine Triphosphate*/metabolism ; Epithelial Cells*/Epithelial Cells*/Epithelial Cells*/metabolism; Humans

• Source: PLoS computational biology [PLoS Comput Biol] 2023 Jun 29; Vol. 19 (6), pp. e1011196. Date of Electronic Publication: 2023 Jun 29 (Print Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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