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  • 1-10 ل  24 نتائج ل ""Organophosphonates""

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Publication : nucleic acids research
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Academic Journal

Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli.

  • Authors : Kopina BJ; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA.; Missoury S

Subjects: Adenosine/Adenosine/Adenosine/*analogs & derivatives ; Escherichia coli Proteins/Escherichia coli Proteins/Escherichia coli Proteins/*chemistry ; RNA, Transfer/RNA, Transfer/RNA, Transfer/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2141-2160.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.

  • Authors : Yamada K; RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA.; Hildebrand S

Subjects: Huntington Disease/Huntington Disease/Huntington Disease/*genetics ; Oligonucleotides/Oligonucleotides/Oligonucleotides/*metabolism ; RNA, Small Interfering/RNA, Small Interfering/RNA, Small Interfering/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2021 Dec 02; Vol. 49 (21), pp. 12069-12088.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

The H-phosphonate approach to the solution phase synthesis of linear and cyclic oligoribonucleotides.

  • Authors : Reese CB; Department of Chemistry, King's College London, Strand, London WC2R 2LS, UK.; Song Q

Subjects: Organophosphonates*; Oligoribonucleotides/Oligoribonucleotides/Oligoribonucleotides/*chemical synthesis; Molecular Structure

  • Source: Nucleic acids research [Nucleic Acids Res] 1999 Feb 15; Vol. 27 (4), pp. 963-71.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Print ISSN: 0305-1048

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Academic Journal

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.

  • Authors : Migawa MT; Ionis Pharmaceuticals, 2855 Gazelle Court, Carlsbad, CA 92010, USA.; Shen W

Subjects: Cell Membrane/Cell Membrane/Cell Membrane/*metabolism ; Cytoplasm/Cytoplasm/Cytoplasm/*metabolism ; Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2019 Jun 20; Vol. 47 (11), pp. 5465-5479.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Subjects: Small interfering RNA; Huntingtin; AcademicSubjects/SCI00010

  • Source: Nucleic Acids Research

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Academic Journal

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.

  • Authors : Haraszti RA; RNA Therapeutics Institute, University of Massachusetts Medical School, 01605 Worcester, MA, USA.; Program in Molecular Medicine, University of Massachusetts Medical School, 01605 Worcester, MA, USA.

Subjects: Organophosphonates/Organophosphonates/Organophosphonates/*pharmacology ; RNA, Small Interfering/RNA, Small Interfering/RNA, Small Interfering/*metabolism ; Vinyl Compounds/Vinyl Compounds/Vinyl Compounds/*pharmacology

  • Source: Nucleic acids research [Nucleic Acids Res] 2017 Jul 27; Vol. 45 (13), pp. 7581-7592.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

  • Authors : Elkayam E; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.

Subjects: RNA Interference*; Argonaute Proteins/Argonaute Proteins/Argonaute Proteins/*chemistry ; Argonaute Proteins/Argonaute Proteins/Argonaute Proteins/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2017 Apr 07; Vol. 45 (6), pp. 3528-3536.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Accurate ab initio prediction of NMR chemical shifts of nucleic acids and nucleic acids/protein complexes.

  • Authors : Victora A; Department of Chemistry and Zukunftskolleg, Universität Konstanz, 78457 Konstanz, Germany.; Möller HM

Subjects: DNA/DNA/DNA/*chemistry ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*chemistry ; Nuclear Magnetic Resonance, Biomolecular/Nuclear Magnetic Resonance, Biomolecular/Nuclear Magnetic Resonance, Biomolecular/*methods

  • Source: Nucleic acids research [Nucleic Acids Res] 2014 Dec 16; Vol. 42 (22), pp. e173. Date of Electronic Publication: 2014 Nov 17.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes.

  • Authors : Šipova H; Institute of Photonics and Electronics AS CR, v.v.i., Chaberská 57, 182 51 Prague, Czech Republic, Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nám. 2., 166 10 Prague, Czech Republic and Faculty of Mathematics and Physics, Charles University in Prague, Ke Karlovu 3, 121 16 Prague, Czech Republic.; Špringer T

Subjects: Escherichia coli/Escherichia coli/Escherichia coli/*enzymology ; Oligonucleotides, Antisense/Oligonucleotides, Antisense/Oligonucleotides, Antisense/*chemistry ; Organophosphonates/Organophosphonates/Organophosphonates/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2014 Apr; Vol. 42 (8), pp. 5378-89. Date of Electronic Publication: 2014 Feb 12.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.

  • Authors : Ndongwe TP; Christopher Bond Life Sciences Center, Department of Molecular Microbiology & Immunology, University of Missouri, School of Medicine, Columbia, MO 65211, USA.; Adedeji AO

Subjects: HIV Reverse Transcriptase/HIV Reverse Transcriptase/HIV Reverse Transcriptase/*chemistry ; HIV Reverse Transcriptase/HIV Reverse Transcriptase/HIV Reverse Transcriptase/*metabolism ; RNA-Directed DNA Polymerase/RNA-Directed DNA Polymerase/RNA-Directed DNA Polymerase/*chemistry

  • Source: Nucleic acids research [Nucleic Acids Res] 2012 Jan; Vol. 40 (1), pp. 345-59. Date of Electronic Publication: 2011 Sep 08.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 ل  24 نتائج ل ""Organophosphonates""