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Academic Journal

Unlocking precision in aptamer engineering: a case study of the thrombin binding aptamer illustrates why modification size, quantity, and position matter.

  • Authors : Murray MT; Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.; Wetmore SD

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/metabolism ; Molecular Dynamics Simulation*

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Oct 14; Vol. 52 (18), pp. 10823-10835.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Aptamer-based assay for high-throughput substrate profiling of RNA decapping enzymes.

  • Authors : Grab K; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.; Doctoral School of Exact and Natural Sciences, University of Warsaw, Żwirki i Wigury 93, 02-089, Warsaw, Poland.

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; High-Throughput Screening Assays*/High-Throughput Screening Assays*/High-Throughput Screening Assays*/methods; Substrate Specificity

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Nov 27; Vol. 52 (21), pp. e100.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain.

  • Authors : Esler MA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/chemistry ; SARS-CoV-2*/SARS-CoV-2*/SARS-CoV-2*/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Nov 27; Vol. 52 (21), pp. 13138-13151.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD.

  • Authors : Lu X; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.; Passalacqua LFM

Subjects: G-Quadruplexes* ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. 8039-8051.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels.

  • Authors : Park KS; Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Republic of Korea.; Biological Clock-based Anti-Aging Convergence RLRC, Korea University, Sejong 30019, Republic of Korea.

Subjects: Adenosine Triphosphate*/Adenosine Triphosphate*/Adenosine Triphosphate*/metabolism ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. 8063-8071.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer/dye pairs.

  • Authors : Zheng R; Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.; Wu R

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Fluorescent Dyes*/Fluorescent Dyes*/Fluorescent Dyes*/chemistry; Humans

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 27; Vol. 52 (15), pp. e67.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Aptamer binding footprints discriminate α-synuclein fibrillar polymorphs from different synucleinopathies.

  • Authors : Bouvier-Müller A; CEA, DRF, Institut of biology JACOB, Molecular Imaging Research Center (MIRCen), Fontenay aux roses 92335, France.; CNRS UMR 9199, Laboratoire des Maladies Neurodégénératives, Fontenay aux roses 92335, France.

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/chemistry ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. 8072-8085.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Resolving the intricate binding of neomycin B to multiple binding motifs of a neomycin-sensing riboswitch aptamer by native top-down mass spectrometry and NMR spectroscopy.

  • Authors : Heel SV; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.; Juen F

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/metabolism ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 May 08; Vol. 52 (8), pp. 4691-4701.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

UTexas Aptamer Database: the collection and long-term preservation of aptamer sequence information.

  • Authors : Askari A; Freshman Research Initiative, The University of Texas, Austin, TX 78712, USA.; Kota S

Subjects: Aptamers, Nucleotide* ; Databases, Nucleic Acid*; Datasets as Topic

  • Source: Nucleic acids research [Nucleic Acids Res] 2024 Jan 05; Vol. 52 (D1), pp. D351-D359.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Selective targeting of parallel G-quadruplex structure using L-RNA aptamer.

  • Authors : Ji D; Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.; Yuan JH

Subjects: G-Quadruplexes* ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/chemistry ; Nucleic Acids*

  • Source: Nucleic acids research [Nucleic Acids Res] 2023 Nov 27; Vol. 51 (21), pp. 11439-11452.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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