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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

• Authors : Robertson, Catherine C; Inshaw, Jamie RJ; Onengut-Gumuscu, Suna

Subjects: Biological Sciences; Genetics; Diabetes

• Source: Nature Genetics. 53(7)

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

• Authors : Barrett, JC; Clayton, DG; Concannon, P

Subjects: Medicin och hälsovetenskap

• Source: Nature genetics. 41(6):703-707

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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

• Authors : Westra, H-J; Martinez-Bonet, M; Onengut-Gumuscu, S

• Source: NATURE GENETICS. 50(10):1366-1374

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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

• Authors : Onengut-Gumuscu, S; Chen, W-M; Burren, O

• Source: NATURE GENETICS. 47(4):381-386

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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.

• Authors : Hu, Xinli¹; Deutsch, Aaron J²; Lenz, Tobias L³

• Source: Nature Genetics. Aug2015, Vol. 47 Issue 8, p898-905. 8p. 2 Diagrams, 1 Chart, 5 Graphs.

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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

• Authors : Kissler, Stephan¹ ; Stern, Patrick¹; Takahashi, Kazue²

• Source: Nature Genetics. Apr2006, Vol. 38 Issue 4, p479-483. 5p. 4 Graphs.

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The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.

• Authors : Wallace, Chris¹ ; Smyth, Deborah J.¹; Maisuria-Armer, Meeta¹

• Source: Nature Genetics. Jan2010, Vol. 42 Issue 1, p68-71. 4p. 3 Charts, 1 Graph.

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

• Authors : Lowe, Christopher E.¹; Cooper, Jason D.¹; Brusko, Todd²

• Source: Nature Genetics. Sep2007, Vol. 39 Issue 9, p1074-1082. 9p. 1 Diagram, 4 Charts, 2 Graphs.

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

• Authors : Todd, John A.¹ ; Walker, Neil M.¹; Cooper, Jason D.¹

• Source: Nature Genetics. Jul2007, Vol. 39 Issue 7, p857-864. 8p. 4 Charts, 1 Graph.

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A functional variant of SUMO4, a new I?Ba modifier, is associated with type 1 diabetes.

• Authors : Guo, Dehuang¹; Manyu Li¹; Yan Zhang¹

• Source: Nature Genetics. Aug2004, Vol. 36 Issue 8, p837-841. 5p.

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