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An inducible long noncoding RNA amplifies DNA damage signaling

• Authors : Kun Qu; Howard Y. Chang; Tiffany Hung

Subjects: Feedback, Physiological; Male; Mice, Knockout

• Source: Nat Genet

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TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

• Authors : Olga Murina; Margaret E. Harley; Michael B. Bober ...

Subjects: Ultraviolet Rays; Ubiquitin-Protein Ligases; Molecular Sequence Data

• Source: Nat GenetHarley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin,

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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

• Authors : Bradshaw, Paul S.^1,2; Stavropoulos, Dimitrios J.^1,2; Meyn, M. Stephen^1,2

• Source: Nature Genetics. Feb2005, Vol. 37 Issue 2, p193-197. 5p.

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Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy.

• Authors : Takashima, Hiroshi; Boerkoel, Cornelius F.; John, Joy

• Source: Nature Genetics. Oct2002, Vol. 32 Issue 2, p267. 6p.

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BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

• Authors : Hartman, Anne-Renee; Ford, James M.

• Source: Nature Genetics. Sep2002, Vol. 32 Issue 1, p180. 5p.

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FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

• Authors : Michael J. Mihatsch; Jérôme Verine; Tobias B. Huber ...

Subjects: DNA Repair; Chronic/etiology; Mutation

• Source: Nat GenetNature Genetics; Vol 44Zhou, W, Otto, E A, Cluckey, A, Airik, R, Hurd, T W, Chaki, M, Diaz, K, Lach, F P, Bennett, G R, Gee, H Y, Ghosh, A K,

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Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

• Authors : Griffith, E; Walker, S; Martin, CA

Subjects: Genetic Linkage; Chromosomes, Human, Pair 22; DCN 2: Functional Neurogenomics

• Source: Nature Genetics, 40, 2, pp. 232-6Griffith, E, Walker, S, Martin, C-A, Vagnarelli, P, Stiff, T, Vernay, B, Al Sanna, N, Saggar, A, Hamel, B, Earnshaw, W C, Jeggo, P

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

• Authors : Sherly Pardo-Reoyo; Kenneth H. Cowan; Magda Sgagias

Subjects: G2 Phase; 0303 health sciences; Blotting, Western

• Source: Nature Genetics. 30:285-289

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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

• Authors : Raquel Blanco; Purificación Muñoz; Juana M. Flores

Subjects: Keratinocytes; Transcriptional Activation; 0303 health sciences

• Source: Nature Genetics. 37:1063-1071

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The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

• Authors : Jiri Bartek; Jiri Lukas; Bret R. Williams

Subjects: 0303 health sciences; Tumor Suppressor Proteins; Cyclin-Dependent Kinase 2

• Source: Nature Genetics. 30:290-294

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