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Academic Journal

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.

  • Authors : van Rhijn N; Manchester Fungal Infection Group, Division of Evolution, Infection and Genomic Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Zhao C

Subjects: Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/genetics ; Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/drug effects ; Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/enzymology

  • Source: Nature communications [Nat Commun] 2024 Jun 11; Vol. 15 (1), pp. 4984. Date of Electronic Publication: 2024 Jun 11.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

An oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli.

  • Authors : Calise DG; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, USA.

Subjects: Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology ; Echinocandins*/Echinocandins*/Echinocandins*/pharmacology ; Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/drug effects

  • Source: Nature communications [Nat Commun] 2024 May 04; Vol. 15 (1), pp. 3770. Date of Electronic Publication: 2024 May 04.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.

  • Authors : Xie J; Graduate Program in Pharmaceutical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.; Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Subjects: Methyltransferases*/Methyltransferases*/Methyltransferases*/metabolism ; Methyltransferases*/Methyltransferases*/Methyltransferases*/genetics ; Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology

  • Source: Nature communications [Nat Commun] 2024 May 20; Vol. 15 (1), pp. 4261. Date of Electronic Publication: 2024 May 20.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1.

  • Authors : Rybak JM; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Xie J

Subjects: Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/drug effects ; Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/metabolism ; Aspergillus fumigatus*/Aspergillus fumigatus*/Aspergillus fumigatus*/genetics

  • Source: Nature communications [Nat Commun] 2024 Apr 29; Vol. 15 (1), pp. 3642. Date of Electronic Publication: 2024 Apr 29.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Tandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population.

  • Authors : Fan X; Department of Infectious Diseases and Clinical Microbiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Subjects: Azoles*/Azoles*/Azoles*/pharmacology ; Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology; Candida tropicalis/Candida tropicalis/Candida tropicalis/genetics

  • Source: Nature communications [Nat Commun] 2023 Dec 15; Vol. 14 (1), pp. 8369. Date of Electronic Publication: 2023 Dec 15.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Genotypic diversity and unrecognized antifungal resistance among populations of Candida glabrata from positive blood cultures.

Subjects: Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology ; Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/therapeutic use ; Sepsis*

  • Source: Nature communications [Nat Commun] 2023 Sep 22; Vol. 14 (1), pp. 5918. Date of Electronic Publication: 2023 Sep 22.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.

  • Authors : Pereira de Sa N; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.; Taouil A

Subjects: Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*pharmacology ; Cryptococcus neoformans/Cryptococcus neoformans/Cryptococcus neoformans/*drug effects

  • Source: Nature communications [Nat Commun] 2021 Oct 07; Vol. 12 (1), pp. 5885. Date of Electronic Publication: 2021 Oct 07.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi.

  • Authors : Hu L; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, Hunan, China.

Subjects: Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology ; Candida albicans*; Humans

  • Source: Nature communications [Nat Commun] 2023 May 12; Vol. 14 (1), pp. 2745. Date of Electronic Publication: 2023 May 12.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance.

  • Authors : Arastehfar A; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07110, USA.; Daneshnia F

Subjects: Antifungal Agents*/Antifungal Agents*/Antifungal Agents*/pharmacology ; Echinocandins*; Drug Tolerance

  • Source: Nature communications [Nat Commun] 2023 Mar 02; Vol. 14 (1), pp. 1183. Date of Electronic Publication: 2023 Mar 02.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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