نتائج البحث

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

• Authors : Sullivan KD; Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, Colorado, USA.; Padilla-Just N

Subjects: Genes, p53*; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*metabolism

• Source: Nature chemical biology [Nat Chem Biol] 2012 Jul; Vol. 8 (7), pp. 646-54. Date of Electronic Publication: 2012 Jun 03.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

• Authors : Reaper PM; Vertex Pharmaceuticals (Europe), Abingdon, Oxfordshire, UK.; Griffiths MR

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*antagonists & inhibitors ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*deficiency

• Source: Nature chemical biology [Nat Chem Biol] 2011 Apr 13; Vol. 7 (7), pp. 428-30. Date of Electronic Publication: 2011 Apr 13.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.

• Authors : Burikhanov, Ravshan¹; Sviripa, Vitaliy M²; Hebbar, Nikhil³

• Source: Nature Chemical Biology. Nov2014, Vol. 10 Issue 11, p924-926. 3p.

تفاصيل العنوان

Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.

• Authors : Phan AT; Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. ; Kuryavyi V

Subjects: Promoter Regions, Genetic*; Biomarkers, Tumor/Biomarkers, Tumor/Biomarkers, Tumor/*genetics ; DNA/DNA/DNA/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2005 Aug; Vol. 1 (3), pp. 167-73. Date of Electronic Publication: 2005 Jul 17.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Print ISSN:

تفاصيل العنوان

LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.

• Authors : Golczak, Marcin; Sears, Avery; Kiser, Philip

Subjects: Acyltransferases; Animals; Humans

• Source: Nature Chemical Biology. 11(1)

تفاصيل العنوان

Protein dynamics: Tuning disorder propensity in p53.

• Authors : Kriwacki, Richard W¹

• Source: Nature Chemical Biology. Dec2014, Vol. 10 Issue 12, p987-988. 2p. 1 Diagram.

تفاصيل العنوان

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.

• Authors : Xu J; Switch Laboratory, Flanders Institute for Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium.; Reumers J

Subjects: Tumor Suppressor Protein p53/Tumor Suppressor Protein p53/Tumor Suppressor Protein p53/*genetics ; Tumor Suppressor Protein p53/Tumor Suppressor Protein p53/Tumor Suppressor Protein p53/*metabolism; Animals

• Source: Nature chemical biology [Nat Chem Biol] 2011 May; Vol. 7 (5), pp. 285-95. Date of Electronic Publication: 2011 Mar 27.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.

• Authors : Wang WJ; 1] State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian Province, China. [2].; Wang Y

Subjects: Autophagy* ; Signal Transduction*; Ketones/Ketones/Ketones/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2014 Feb; Vol. 10 (2), pp. 133-40. Date of Electronic Publication: 2013 Dec 08.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.

• Authors : James LI; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Barsyte-Lovejoy D

Subjects: Drug Discovery*; Benzamides/Benzamides/Benzamides/*pharmacology ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2013 Mar; Vol. 9 (3), pp. 184-91. Date of Electronic Publication: 2013 Jan 06.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.

• Authors : Liu F; Chemical Biology Laboratory, Molecular Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, USA.; Park JE

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*chemistry ; Histidine/Histidine/Histidine/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2011 Jul 17; Vol. 7 (9), pp. 595-601. Date of Electronic Publication: 2011 Jul 17.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Electronic Cited Medium: Internet ISSN:

تفاصيل العنوان