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Molecular probes: Getting lucky in the lysosome.

• Authors : Goddard-Borger, Ethan D¹; Wennekes, Tom¹; Withers, Stephen G¹

• Source: Nature Chemical Biology. Dec2010, Vol. 6 Issue 12, p881-883. 3p. 1 Diagram.

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.

• Authors : Stewart, Michelle L.^1,2; Fire, Emiko³; Keating, Amy E.³

• Source: Nature Chemical Biology. Aug2010, Vol. 6 Issue 8, p595-601. 7p. 1 Diagram, 4 Graphs.

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The promise and peril of chemical probes.

• Authors : Arrowsmith, Cheryl H¹; Audia, James E²; Austin, Christopher³

• Source: Nature Chemical Biology. Aug2015, Vol. 11 Issue 8, p536-541. 6p. 3 Diagrams, 2 Charts.

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Probing the epigenome.

• Authors : Huston A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Arrowsmith CH

Subjects: Molecular Probes*/Molecular Probes*/Molecular Probes*/chemical synthesis ; Molecular Probes*/Molecular Probes*/Molecular Probes*/therapeutic use; Epigenomics/Epigenomics/Epigenomics/*methods

• Source: Nature chemical biology [Nat Chem Biol] 2015 Aug; Vol. 11 (8), pp. 542-5.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN:

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A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

• Authors : Dale T; School of Bioscience, Cardiff University, Cardiff, UK.; Clarke PA

Subjects: Colonic Neoplasms/Colonic Neoplasms/Colonic Neoplasms/*drug therapy ; Colonic Neoplasms/Colonic Neoplasms/Colonic Neoplasms/*metabolism ; Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 8/*antagonists & inhibitors

• Source: Nature chemical biology [Nat Chem Biol] 2015 Dec; Vol. 11 (12), pp. 973-980. Date of Electronic Publication: 2015 Oct 26.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Combating neurodegenerative disease with chemical probes and model systems.

• Authors : Narayan P; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.; Ehsani S

Subjects: Models, Biological*; Molecular Probes/Molecular Probes/Molecular Probes/*chemistry ; Molecular Probes/Molecular Probes/Molecular Probes/*therapeutic use

• Source: Nature chemical biology [Nat Chem Biol] 2014 Nov; Vol. 10 (11), pp. 911-20. Date of Electronic Publication: 2014 Oct 17.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Probing questions.

Subjects: Information Dissemination/Information Dissemination/Information Dissemination/*ethics ; Molecular Probes/Molecular Probes/Molecular Probes/*chemistry; Biomedical Research/Biomedical Research/Biomedical Research/instrumentation

• Source: Nature chemical biology [Nat Chem Biol] 2015 Aug; Vol. 11 (8), pp. 533.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN:

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Covalent docking of large libraries for the discovery of chemical probes.

• Authors : London N; Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, California, USA.; Miller RM

Subjects: Molecular Docking Simulation*; Molecular Probes/Molecular Probes/Molecular Probes/*chemistry ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2014 Dec; Vol. 10 (12), pp. 1066-72. Date of Electronic Publication: 2014 Oct 26.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Putting small molecules in the lead.

• Authors : Jaroch, Stefan¹ ; Weinmann, Hilmar¹

• Source: Nature Chemical Biology. Sep2005, Vol. 1 Issue 4, p180-183. 4p.

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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.

• Authors : James LI; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Barsyte-Lovejoy D

Subjects: Drug Discovery*; Benzamides/Benzamides/Benzamides/*pharmacology ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*chemistry

• Source: Nature chemical biology [Nat Chem Biol] 2013 Mar; Vol. 9 (3), pp. 184-91. Date of Electronic Publication: 2013 Jan 06.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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