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Academic Journal

Terazosin activates Pgk1 and Hsp90 to promote stress resistance.

  • Authors : Chen X; 1] State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing, China. [2] Beijing Institute for Brain Disorder and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Zhao C

Subjects: Adrenergic alpha-1 Receptor Antagonists/Adrenergic alpha-1 Receptor Antagonists/Adrenergic alpha-1 Receptor Antagonists/*pharmacology ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*drug effects ; Phosphoglycerate Kinase/Phosphoglycerate Kinase/Phosphoglycerate Kinase/*drug effects

  • Source: Nature chemical biology [Nat Chem Biol] 2015 Jan; Vol. 11 (1), pp. 19-25. Date of Electronic Publication: 2014 Nov 10.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

  • Authors : Patel PD; 1] Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, New York, New York, USA. [2] Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York, USA. [3].; Yan P

Subjects: HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*antagonists & inhibitors ; Neoplasms/Neoplasms/Neoplasms/*metabolism ; Purines/Purines/Purines/*pharmacology

  • Source: Nature chemical biology [Nat Chem Biol] 2013 Nov; Vol. 9 (11), pp. 677-84. Date of Electronic Publication: 2013 Sep 01.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

  • Authors : Moulick K; Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, New York, New York, USA.; Ahn JH

Subjects: Gene Expression Regulation, Neoplastic/Gene Expression Regulation, Neoplastic/Gene Expression Regulation, Neoplastic/*physiology ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*metabolism ; Neoplasms/Neoplasms/Neoplasms/*metabolism

  • Source: Nature chemical biology [Nat Chem Biol] 2011 Sep 25; Vol. 7 (11), pp. 818-26. Date of Electronic Publication: 2011 Sep 25.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Electronic Cited Medium: Internet ISSN:

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Periodical

Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer.

Subjects: Gene Expression Regulation, Neoplastic*; Carcinoma, Small Cell/Carcinoma, Small Cell/Carcinoma, Small Cell/*metabolism ; HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/HSP90 Heat-Shock Proteins/*physiology

  • Source: Nature chemical biology [Nat Chem Biol] 2007 Aug; Vol. 3 (8), pp. 455-7.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Print ISSN: 1552-4450

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Academic Journal

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

  • Authors : Polier S; Medical Research Council Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK. ; Samant RS

Subjects: Adenosine Triphosphate/Adenosine Triphosphate/Adenosine Triphosphate/*antagonists & inhibitors ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; Chaperonins/Chaperonins/Chaperonins/*metabolism

  • Source: Nature chemical biology [Nat Chem Biol] 2013 May; Vol. 9 (5), pp. 307-12. Date of Electronic Publication: 2013 Mar 17.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

  • Authors : Rodina A; Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.; Vilenchik M

Subjects: Apoptosis*; Carcinoma, Small Cell/Carcinoma, Small Cell/Carcinoma, Small Cell/*drug therapy ; Carcinoma, Small Cell/Carcinoma, Small Cell/Carcinoma, Small Cell/*metabolism

  • Source: Nature chemical biology [Nat Chem Biol] 2007 Aug; Vol. 3 (8), pp. 498-507. Date of Electronic Publication: 2007 Jul 01.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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