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  • 1-10 ل  46 نتائج ل ""HEK293 Cells""

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Publication : molecular neurodegeneration
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Academic Journal

Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency

Subjects: Brain Disorders; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Stem Cell Research

  • Source: Molecular Neurodegeneration. 15(1)

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Academic Journal

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.

  • Authors : Qiao W; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.; Chen Y

Subjects: Amyloidogenic Proteins* ; Amyloid beta-Peptides*; Humans

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2023 Jan 31; Vol. 18 (1), pp. 8. Date of Electronic Publication: 2023 Jan 31.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier.

  • Authors : Kisler K; Department of Physiology and Neuroscience and the Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, 1501 San Pablo St, Los Angeles, CA, 90089, USA.; Sagare AP

Subjects: Antimalarials*/Antimalarials*/Antimalarials*/pharmacology ; Antimalarials*/Antimalarials*/Antimalarials*/metabolism ; Antimalarials*/Antimalarials*/Antimalarials*/therapeutic use

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2023 Jan 27; Vol. 18 (1), pp. 7. Date of Electronic Publication: 2023 Jan 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.

  • Authors : Brody AH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Nies SH

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/pathology ; Tauopathies*/Tauopathies*/Tauopathies*/metabolism; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2022 May 03; Vol. 17 (1), pp. 32. Date of Electronic Publication: 2022 May 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.

  • Authors : Goodwin MS; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, Florida, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA.

Subjects: Dependovirus* ; Gene Expression* ; Gene Transfer Techniques*

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2020 Mar 02; Vol. 15 (1), pp. 15. Date of Electronic Publication: 2020 Mar 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Subjects: Mice, Knockout; Proteomics; Amyloid beta-Peptides

  • Source: Molecular Neurodegeneration. 17

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Academic Journal

A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.

  • Authors : Landeck N; Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, Lund University, BMC D11, 22184, Lund, Sweden. .; Hall H

Subjects: Brain/Brain/Brain/*metabolism ; Parkinson Disease/Parkinson Disease/Parkinson Disease/*metabolism ; alpha-Synuclein/alpha-Synuclein/alpha-Synuclein/*metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2016 Aug 22; Vol. 11 (1), pp. 61. Date of Electronic Publication: 2016 Aug 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.

  • Authors : Zhang X; Department of Neurobiology, The University of Chicago, 947 E. 58th St. MC0928, Chicago, Il 60637, USA. .; Yu CJ

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*chemistry ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*chemistry; Amino Acid Sequence

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Aug 22; Vol. 10, pp. 39. Date of Electronic Publication: 2015 Aug 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

  • Authors : Bettens K; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .

Subjects: Mutation, Missense*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Clusterin/Clusterin/Clusterin/*metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Jul 16; Vol. 10, pp. 30. Date of Electronic Publication: 2015 Jul 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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Academic Journal

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.

  • Authors : Ceballos-Diaz C; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA.; Rosario AM

Subjects: Mutation, Missense* ; Point Mutation*; Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/Amyotrophic Lateral Sclerosis/*genetics

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2015 Jul 08; Vol. 10, pp. 25. Date of Electronic Publication: 2015 Jul 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326

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  • 1-10 ل  46 نتائج ل ""HEK293 Cells""