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In silico and in vitro study of FLT3 inhibitors and their application in acute myeloid leukemia.

• Authors : Carranza-Aranda AS; Biomedicine and Ecology Molecular Markers Laboratory, Department of Cellular and Molecular Biology, Biological and Agricultural Sciences Campus, University of Guadalajara, Zapopan, Jalisco 44600, Mexico.; Jave-Suárez LF

Subjects: fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/genetics ; fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/fms-Like Tyrosine Kinase 3*/metabolism

• Source: Molecular medicine reports [Mol Med Rep] 2024 Dec; Vol. 30 (6). Date of Electronic Publication: 2024 Oct 11.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Tetramethylpyrazine alleviates endoplasmic reticulum stress‑activated apoptosis and related inflammation in chondrocytes.

• Authors : Hu S; Joint and Traumatology Department, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, P.R. China.; Wang S

Subjects: Chondrocytes/Chondrocytes/Chondrocytes/*metabolism ; Endoplasmic Reticulum Stress/Endoplasmic Reticulum Stress/Endoplasmic Reticulum Stress/*drug effects ; Pyrazines/Pyrazines/Pyrazines/*pharmacology

• Source: Molecular medicine reports [Mol Med Rep] 2022 Jan; Vol. 25 (1). Date of Electronic Publication: 2021 Nov 15.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Identifying the mechanisms underlying the protective effect of tetramethylpyrazine against cisplatin‑induced in vitro ototoxicity in HEI‑OC1 auditory cells using gene expression profiling.

• Authors : Guan G; Department of Otolaryngology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.; He X

Subjects: Abietanes/Abietanes/Abietanes/*pharmacology ; Hearing Loss, Sensorineural/Hearing Loss, Sensorineural/Hearing Loss, Sensorineural/*metabolism ; Pyrazines/Pyrazines/Pyrazines/*pharmacology

• Source: Molecular medicine reports [Mol Med Rep] 2020 Dec; Vol. 22 (6), pp. 5053-5068. Date of Electronic Publication: 2020 Oct 23.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Synthesis of folate‑chitosan nanoparticles loaded with ligustrazine to target folate receptor positive cancer cells.

• Authors : Cheng L; Department of Pharmacy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.; Ma H

Subjects: Chitosan/Chitosan/Chitosan/*chemical synthesis ; Folate Receptors, GPI-Anchored/Folate Receptors, GPI-Anchored/Folate Receptors, GPI-Anchored/*metabolism ; Folic Acid/Folic Acid/Folic Acid/*chemical synthesis

• Source: Molecular medicine reports [Mol Med Rep] 2017 Aug; Vol. 16 (2), pp. 1101-1108. Date of Electronic Publication: 2017 Jun 09.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1α-VEGF pathway.

• Authors : CHENG YANG^1,2; YUE XU¹; HUANJIAO ZHOU¹

• Source: Molecular Medicine Reports. 2016, Vol. 13 Issue 2, p1287-1296. 10p.

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Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury.

• Authors : Huang W; Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China.; Yang Y

Subjects: Myocardial Reperfusion Injury/Myocardial Reperfusion Injury/Myocardial Reperfusion Injury/*drug therapy ; Myocytes, Cardiac/Myocytes, Cardiac/Myocytes, Cardiac/*drug effects ; Pyrazines/Pyrazines/Pyrazines/*administration & dosage

• Source: Molecular medicine reports [Mol Med Rep] 2016 Nov; Vol. 14 (5), pp. 4537-4544. Date of Electronic Publication: 2016 Oct 11.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway.

• Authors : Chen XL; Department of Surgery, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.; Fu JP

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*metabolism

• Source: Molecular medicine reports [Mol Med Rep] 2015 Dec; Vol. 12 (6), pp. 8229-36. Date of Electronic Publication: 2015 Oct 23.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Porcupine inhibitor LGK‑974 inhibits Wnt/β‑catenin signaling and modifies tumor‑associated macrophages resulting in inhibition of the malignant behaviors of non‑small cell lung cancer cells.

• Authors : Tang Y; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.; Jiang M

Subjects: Acyltransferases/Acyltransferases/Acyltransferases/*antagonists & inhibitors ; Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/Carcinoma, Non-Small-Cell Lung/*drug therapy ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

• Source: Molecular medicine reports [Mol Med Rep] 2021 Aug; Vol. 24 (2). Date of Electronic Publication: 2021 Jun 03.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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miR‑181d promotes cell proliferation via the IGF1/PI3K/AKT axis in glioma.

• Authors : Tang D; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.; Gao W

Subjects: Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*metabolism ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*genetics ; Glioma/Glioma/Glioma/*metabolism

• Source: Molecular medicine reports [Mol Med Rep] 2020 Nov; Vol. 22 (5), pp. 3804-3812. Date of Electronic Publication: 2020 Aug 26.Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Tetramethylpyrazine alleviates acute kidney injury by inhibiting NLRP3/HIF‑1α and apoptosis

• Authors : Wangnan Sun; Zhiqiang Wang; Fu Qi

Subjects: Male; 0303 health sciences; Cell Survival

• Source: Mol Med Rep

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