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  • 1-10 ل  89 نتائج ل ""TOR Serine-Threonine Kinases""

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Publication : molecular cancer
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Academic Journal

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.

Subjects: AKT inhibitors; ATP-competitive mTOR inhibitors; Allosteric mTOR inhibitors

  • Source: Molecular Cancer. 22(1)

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Academic Journal

A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway.

  • Authors : Huang B; College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P.R. China.; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563006, P.R. China.

Subjects: Carcinoma, Renal Cell*/Carcinoma, Renal Cell*/Carcinoma, Renal Cell*/metabolism ; Kidney Neoplasms*/Kidney Neoplasms*/Kidney Neoplasms*/genetics; Animals

  • Source: Molecular cancer [Mol Cancer] 2024 Feb 15; Vol. 23 (1), pp. 34. Date of Electronic Publication: 2024 Feb 15.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.

  • Authors : Zhang X; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.; Wang S

Subjects: Gene Expression Regulation, Neoplastic*; Adenocarcinoma/Adenocarcinoma/Adenocarcinoma/*genetics ; MicroRNAs/MicroRNAs/MicroRNAs/*genetics

  • Source: Molecular cancer [Mol Cancer] 2019 Feb 04; Vol. 18 (1), pp. 20. Date of Electronic Publication: 2019 Feb 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

The role of RICTOR downstream of receptor tyrosine kinase in cancers.

  • Authors : Jebali A; INSERM, U976, Centre de Recherche sur la Peau, Hôpital Saint Louis, F-75010, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, Paris, France.; Univ Paris Diderot, Sorbonne Paris Cité, UMR 976, F-75010, Paris, France.

Subjects: Neoplasms/Neoplasms/Neoplasms/*drug therapy ; Rapamycin-Insensitive Companion of mTOR Protein/Rapamycin-Insensitive Companion of mTOR Protein/Rapamycin-Insensitive Companion of mTOR Protein/*metabolism ; Receptor Protein-Tyrosine Kinases/Receptor Protein-Tyrosine Kinases/Receptor Protein-Tyrosine Kinases/*metabolism

  • Source: Molecular cancer [Mol Cancer] 2018 Feb 19; Vol. 17 (1), pp. 39. Date of Electronic Publication: 2018 Feb 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Expression of mTOR in normal and pathological conditions.

  • Authors : Marques-Ramos A; H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal. .; Cervantes R

Subjects: Multiprotein Complexes*/Multiprotein Complexes*/Multiprotein Complexes*/metabolism ; Sirolimus*; Humans

  • Source: Molecular cancer [Mol Cancer] 2023 Jul 15; Vol. 22 (1), pp. 112. Date of Electronic Publication: 2023 Jul 15.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors.

  • Authors : Faes S; Lausanne University Hospital CHUV and University of Lausanne, Pavillon 4, Av. de Beaumont, 1011, Lausanne, Switzerland.; Duval AP

Subjects: Tumor Microenvironment*; Acids/Acids/Acids/*adverse effects ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy

  • Source: Molecular cancer [Mol Cancer] 2016 Dec 05; Vol. 15 (1), pp. 78. Date of Electronic Publication: 2016 Dec 05.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Significance of filamin A in mTORC2 function in glioblastoma.

  • Authors : Chantaravisoot N; Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.; Wongkongkathep P

Subjects: Filamins/Filamins/Filamins/*metabolism ; Glioblastoma/Glioblastoma/Glioblastoma/*metabolism ; Multiprotein Complexes/Multiprotein Complexes/Multiprotein Complexes/*metabolism

  • Source: Molecular cancer [Mol Cancer] 2015 Jul 02; Vol. 14, pp. 127. Date of Electronic Publication: 2015 Jul 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

mTOR inhibition and levels of the DNA repair protein MGMT in T98G glioblastoma cells.

  • Authors : Smalley S; Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK. .; Chalmers AJ

Subjects: Antineoplastic Agents, Alkylating/Antineoplastic Agents, Alkylating/Antineoplastic Agents, Alkylating/*pharmacology ; DNA Modification Methylases/DNA Modification Methylases/DNA Modification Methylases/*antagonists & inhibitors ; DNA Repair/DNA Repair/DNA Repair/*drug effects

  • Source: Molecular cancer [Mol Cancer] 2014 Jun 08; Vol. 13, pp. 144. Date of Electronic Publication: 2014 Jun 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma.

Subjects: Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects; Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Proto-Oncogene Proteins c-met/Proto-Oncogene Proteins c-met/Proto-Oncogene Proteins c-met/*antagonists & inhibitors

  • Source: Molecular cancer [Mol Cancer] 2014 Aug 07; Vol. 13, pp. 185. Date of Electronic Publication: 2014 Aug 07.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.

  • Authors : Song R; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.; Ma S

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/genetics ; Liver Neoplasms*/Liver Neoplasms*/Liver Neoplasms*/genetics ; MicroRNAs*/MicroRNAs*/MicroRNAs*/genetics

  • Source: Molecular cancer [Mol Cancer] 2023 Jan 23; Vol. 22 (1), pp. 16. Date of Electronic Publication: 2023 Jan 23.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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  • 1-10 ل  89 نتائج ل ""TOR Serine-Threonine Kinases""