نتائج البحث

N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2.

• Authors : Wen D; Department of Hematology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.; Xiao H

Subjects: Adenosine*/Adenosine*/Adenosine*/analogs & derivatives ; Adenosine*/Adenosine*/Adenosine*/metabolism ; Cell Proliferation*

• Source: Molecular cancer [Mol Cancer] 2024 May 31; Vol. 23 (1), pp. 116. Date of Electronic Publication: 2024 May 31.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

تفاصيل العنوان

A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway.

• Authors : Huang, Bo^1,2 (AUTHOR); Ren, Junwu¹ (AUTHOR); Ma, Qiang¹ (AUTHOR)

• Source: Molecular Cancer. 2/15/2024, Vol. 23 Issue 1, p1-27. 27p.

تفاصيل العنوان

N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2

• Authors : Diguang Wen; Hang Xiao; Yueyi Gao

Subjects: Acute myeloid leukemia; SUMO; SENP1

• Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)

تفاصيل العنوان

A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway

• Authors : Bo Huang; Junwu Ren; Qiang Ma

Subjects: Clear cell renal cell carcinoma; CircPDHK1; Novel peptide

• Source: Molecular Cancer, Vol 23, Iss 1, Pp 1-27 (2024)

تفاصيل العنوان

Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway.

• Authors : Fei D; Department of Anesthesiology, Luzhou People's Hospital, Southwest Medical University, Luzhou, 646000, Sichuan, PR China.; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, 646000, Sichuan, PR China.

Subjects: Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/genetics ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/pathology ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/metabolism

• Source: Molecular cancer [Mol Cancer] 2024 Aug 06; Vol. 23 (1), pp. 159. Date of Electronic Publication: 2024 Aug 06.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

تفاصيل العنوان

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

• Authors : Qiwei Jiang; Nana Zheng; Lang Bu

Subjects: PDK1; SPOP; AKT

• Source: Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)

تفاصيل العنوان

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.

• Authors : Jiang, Qiwei¹ (AUTHOR); Zheng, Nana² (AUTHOR); Bu, Lang¹ (AUTHOR)

• Source: Molecular Cancer. 8/5/2021, Vol. 20 Issue 1, p1-18. 18p.

تفاصيل العنوان

YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer.

• Authors : Li J; Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.; Xie H

Subjects: Gene Expression Regulation, Neoplastic* ; RNA Stability*; Adenosine/Adenosine/Adenosine/*analogs & derivatives

• Source: Molecular cancer [Mol Cancer] 2020 Oct 29; Vol. 19 (1), pp. 152. Date of Electronic Publication: 2020 Oct 29.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

تفاصيل العنوان

Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma

• Authors : Lassen, Amanda; Atefi, Mohammad; Robert, Lidia

Subjects: Biomedical and Clinical Sciences; Oncology and Carcinogenesis; Cancer

• Source: Molecular Cancer. 13(1)

تفاصيل العنوان

Correction: Histone acetyltransferase PCAF Up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling

• Authors : Xin Zheng; Xiaohong Gai; Feihu Ding

Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282

• Source: Molecular Cancer, Vol 21, Iss 1, Pp 1-5 (2022)

تفاصيل العنوان