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Academic Journal

Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation.

  • Authors : Puyalto A; Department of Medical Oncology, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.; Program in Solid Tumors, Cancer Division, Cima Universidad de Navarra, CCUN, Av. Pio XII, 55, 31008, Pamplona, Spain.

Subjects: Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/drug therapy ; Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/genetics ; Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/pathology

  • Source: Molecular cancer [Mol Cancer] 2024 Apr 20; Vol. 23 (1), pp. 78. Date of Electronic Publication: 2024 Apr 20.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib.

  • Authors : Ge W; Department of Oncology and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.; Department of Medical Oncology, Shanghai Medical College, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, People's Republic of China.

Subjects: Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/drug therapy ; Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/pathology

  • Source: Molecular cancer [Mol Cancer] 2024 Mar 08; Vol. 23 (1), pp. 48. Date of Electronic Publication: 2024 Mar 08.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Report

Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold.

  • Authors : Schmäche T; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, Dresden, 01307, Germany.; National Center for Tumor Diseases Dresden (NCT/UCC), a partnership between DKFZ, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.

Subjects: Stomach Neoplasms*/Stomach Neoplasms*/Stomach Neoplasms*/drug therapy ; Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/drug therapy ; Carbamates*

  • Source: Molecular cancer [Mol Cancer] 2024 Jan 10; Vol. 23 (1), pp. 10. Date of Electronic Publication: 2024 Jan 10.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Aberrant R-loop-mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis.

  • Authors : Zhang S; Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, Guizhou Medical University, Guiyang, China.; Liu Y

Subjects: Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics ; Fanconi Anemia*Fanconi Anemia, Complementation Group I

  • Source: Molecular cancer [Mol Cancer] 2024 Jan 10; Vol. 23 (1), pp. 11. Date of Electronic Publication: 2024 Jan 10.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis.

  • Authors : Stoecklein NH; General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany. .; Fluegen G

Subjects: Pancreatic Neoplasms*/Pancreatic Neoplasms*/Pancreatic Neoplasms*/diagnosis ; Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/diagnosis ; Neoplastic Cells, Circulating*/Neoplastic Cells, Circulating*/Neoplastic Cells, Circulating*/pathology

  • Source: Molecular cancer [Mol Cancer] 2023 Nov 13; Vol. 22 (1), pp. 181. Date of Electronic Publication: 2023 Nov 13.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7.

  • Authors : Li K; Department of Otorhinolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, China.; Peng ZY

Subjects: Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/drug therapy ; Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/genetics ; F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/F-Box-WD Repeat-Containing Protein 7*/genetics

  • Source: Molecular cancer [Mol Cancer] 2023 Jul 01; Vol. 22 (1), pp. 103. Date of Electronic Publication: 2023 Jul 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Clinically conserved genomic subtypes of gastric adenocarcinoma.

  • Authors : Jeong YS; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1058, Houston, TX, 77030, USA.; Eun YG

Subjects: Epstein-Barr Virus Infections* ; Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/genetics ; Adenocarcinoma*/Adenocarcinoma*/Adenocarcinoma*/therapy

  • Source: Molecular cancer [Mol Cancer] 2023 Sep 06; Vol. 22 (1), pp. 147. Date of Electronic Publication: 2023 Sep 06.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications.

  • Authors : Park JK; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.

Subjects: Tumor Microenvironment*/Tumor Microenvironment*/Tumor Microenvironment*/genetics ; Single-Cell Analysis* ; Liver Neoplasms*/Liver Neoplasms*/Liver Neoplasms*/secondary

  • Source: Molecular cancer [Mol Cancer] 2024 May 03; Vol. 23 (1), pp. 87. Date of Electronic Publication: 2024 May 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma.

  • Authors : Gautam SK; Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. .; Batra SK

Subjects: Pancreatic Neoplasms* ; Adenocarcinoma* ; Carcinoma, Pancreatic Ductal*

  • Source: Molecular cancer [Mol Cancer] 2023 Jul 24; Vol. 22 (1), pp. 118. Date of Electronic Publication: 2023 Jul 24.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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Academic Journal

m 6 A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma.

  • Authors : Fang H; Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, Shandong, China.; Key Laboratory of Spatiotemporal Single-Cell Technologies and Translational Medicine, Yantai, 264000, Shandong, China.

Subjects: Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/Adenocarcinoma of Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/genetics; Humans

  • Source: Molecular cancer [Mol Cancer] 2023 Jun 23; Vol. 22 (1), pp. 99. Date of Electronic Publication: 2023 Jun 23.Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598

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