نتائج البحث

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down's syndrome mouse model.

• Authors : Urbano-Gámez, Jesús David^1,2 (AUTHOR); Casañas, Juan José^1,2 (AUTHOR); Benito, Itziar^1,2,3 (AUTHOR)

• Source: Molecular Brain. 5/25/2021, Vol. 14 Issue 1, p1-16. 16p.

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Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

• Authors : Hiroko Kotajima-Murakami; Toshiyuki Kobayashi; Hirofumi Kashii

Subjects: Autism spectrum disorder; mTOR signaling pathway; Valproic acid

• Source: Molecular Brain, Vol 12, Iss 1, Pp 1-14 (2019)

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Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model

• Authors : Jesús David Urbano-Gámez; Juan José Casañas; Itziar Benito

Subjects: mGluR-LTD; mTOR; Dendritic spines

• Source: Molecular Brain, Vol 14, Iss 1, Pp 1-16 (2021)

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Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses.

• Authors : Honoré E; Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning (CIRCA) and Research Group on Neural Signaling and Circuitry (GRSNC), Université de Montréal, P.O. Box 6128, Station Downtown, QC, H3C 3J7, Montreal, Canada.; Lacaille JC

Subjects: Long-Term Potentiation*/Long-Term Potentiation*/Long-Term Potentiation*/physiology ; Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/Mechanistic Target of Rapamycin Complex 1*/metabolism ; Spatial Learning*/Spatial Learning*/Spatial Learning*/physiology

• Source: Molecular brain [Mol Brain] 2022 Dec 21; Vol. 15 (1), pp. 101. Date of Electronic Publication: 2022 Dec 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606

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mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination.

• Authors : Khlaifia A; Department of Neurosciences, Center for Interdisciplinary Research on Brain and Learning (CIRCA) and Research Group On Neural Signaling and Circuitry (GRSNC), Université de Montréal, P.O. Box 6128, Station Downtown, QC, H3C 3J7, Montreal, Canada.; Department of Psychology, University of Toronto Scarborough, ON, M1C1A4, Toronto, Canada.

Subjects: CA1 Region, Hippocampal*/CA1 Region, Hippocampal*/CA1 Region, Hippocampal*/metabolism ; Fear*/Fear*/Fear*/physiology ; Hippocampus*/Hippocampus*/Hippocampus*/metabolism

• Source: Molecular brain [Mol Brain] 2022 Jun 17; Vol. 15 (1), pp. 56. Date of Electronic Publication: 2022 Jun 17.Publisher: BioMed Central Country of Publication: England NLM ID: 101468876 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-6606

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Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation

• Authors : Fredrick E. Henry; William Hockeimer; Alex Chen

Subjects: Neurology. Diseases of the nervous system; RC346-429

• Source: Molecular Brain, Vol 10, Iss 1, Pp 1-17 (2017)

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Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero.

• Authors : Hagino, Yoko¹; Ikeda, Kazutaka¹; Kotajima-Murakami, Hiroko^1,2

• Source: Molecular Brain. 1/8/2019, Vol. 12 Issue 1, pN.PAG-N.PAG. 1p.

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Mechanistic target of rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation.

• Authors : Henry, Fredrick E.^1,2,3; Hockeimer, William^2,3; Chen, Alex^1,2,3

• Source: Molecular Brain. 10/30/2017, Vol. 10, p1-17. 17p.

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In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.

• Authors : Xing, Viktoria; Biggar, Kyle; Ferguson, Stephen S. G.

Subjects: ALPHA-synuclein; PARKINSON'S disease; MTOR inhibitors

• Source: Molecular Brain; 2/15/2024, Vol. 17 Issue 1, p1-10, 10p

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ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation.

• Authors : Seung-Hee Lee^1,2; Jaehoon Shim¹; Ye-Hwang Cheong¹

• Source: Molecular Brain. 10/22/2016, Vol. 9, p1-12. 12p.

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