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Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 transgenic mice

• Authors : Longfei Xu; Mingzhe Li; Aili Wei

Subjects: Physical exercise; E3 ubiquitin ligase; Alzheimer’s disease

• Source: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)

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Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau and improve cognitive ability in APP/PS1 transgenic mice.

• Authors : Xu L; Institute of Environmental and Operational Medicine, Academy of Military Medicine Sciences, Academy of Military Sciences, 1 Dali Road, Heping District, Tianjin, 300050, People's Republic of China.; Tianjin Key Laboratory of Exercise Physiology & Sports Medicine, Tianjin University of Sport, Tianjin, 301617, People's Republic of China.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/genetics ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/therapy

• Source: Journal of neuroinflammation [J Neuroinflammation] 2022 Oct 04; Vol. 19 (1), pp. 243. Date of Electronic Publication: 2022 Oct 04.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site.

• Authors : Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Parcon PA

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Interleukin-1beta/Interleukin-1beta/Interleukin-1beta/*metabolism ; NEDD8 Protein/NEDD8 Protein/NEDD8 Protein/*metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2019 Dec 27; Vol. 16 (1), pp. 275. Date of Electronic Publication: 2019 Dec 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2.

• Authors : Zheng S; Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, 250012, People's Republic of China.; Li Y

Subjects: Brain Ischemia*/Brain Ischemia*/Brain Ischemia*/metabolism ; Ischemic Stroke*/Ischemic Stroke*/Ischemic Stroke*/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinase 2*/Receptor-Interacting Protein Serine-Threonine Kinase 2*/Receptor-Interacting Protein Serine-Threonine Kinase 2*/metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2023 Nov 27; Vol. 20 (1), pp. 281. Date of Electronic Publication: 2023 Nov 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation

• Authors : Sinéad Kinsella; Michael Fichtner; Orla Watters

Subjects: A20; Bid; E3 ubiquitin ligase

• Source: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-12 (2018)

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ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation.

• Authors : Clarkson, Benjamin D. S.^1,2 (AUTHOR) ; Grund, Ethan^1,3 (AUTHOR); David, Kenneth⁴ (AUTHOR)

• Source: Journal of Neuroinflammation. 10/20/2022, Vol. 19 Issue 1, p1-23. 23p.

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Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

• Authors : Meenakshisundaram Balasubramaniam; Paul A. Parcon; Chhanda Bose

Subjects: IL-1β; GSK3β; PINK1

• Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)

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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.

• Authors : Kinsella S; Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.; Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA.

Subjects: BH3 Interacting Domain Death Agonist Protein/BH3 Interacting Domain Death Agonist Protein/BH3 Interacting Domain Death Agonist Protein/*deficiency ; Neuroglia/Neuroglia/Neuroglia/*metabolism ; Toll-Like Receptor 3/Toll-Like Receptor 3/Toll-Like Receptor 3/*metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2018 May 02; Vol. 15 (1), pp. 130. Date of Electronic Publication: 2018 May 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection.

• Authors : Zhu, Shuo^1,2,3 (AUTHOR); Tao, Mengying^1,2,3 (AUTHOR); Li, Yunchuan^1,2,3 (AUTHOR)

• Source: Journal of Neuroinflammation. 7/21/2023, Vol. 20 Issue 1, p1-15. 15p.

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TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats.

• Authors : Liang H; Department of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Physiology and Pharmacology and Department of Anesthesiology, Loma Linda University, 11041 Campus St, Risley Hall, Room 219, Loma Linda, CA, 92354, USA.

Subjects: Caspase 8/Caspase 8/Caspase 8/*metabolism ; Infarction, Middle Cerebral Artery/Infarction, Middle Cerebral Artery/Infarction, Middle Cerebral Artery/*metabolism ; Inflammation Mediators/Inflammation Mediators/Inflammation Mediators/*metabolism

• Source: Journal of neuroinflammation [J Neuroinflammation] 2021 Feb 02; Vol. 18 (1), pp. 40. Date of Electronic Publication: 2021 Feb 02.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094

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