نتائج البحث

Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy.

• Authors : Ma, Jian-Chao¹ (AUTHOR); Luo, Tingting¹ (AUTHOR); Feng, Binyang¹ (AUTHOR)

• Source: Journal of Nanobiotechnology. 10/4/2023, Vol. 21 Issue 1, p1-18. 18p.

تفاصيل العنوان

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis.

• Authors : Figueroa-Valdés AI; Laboratorio de Medicina Nano-Regenerativa, Centro de Investigación e Innovación Biomédica (CiiB), Universidad de los Andes, Santiago, Chile.; IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile.

Subjects: Extracellular Vesicles* ; Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/metabolism ; Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/Mesenchymal Stem Cells*/cytology

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Jan 13; Vol. 23 (1), pp. 13. Date of Electronic Publication: 2025 Jan 13.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence.

• Authors : Kong K; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, P.R. China.; Li B

Subjects: Chondrocytes*/Chondrocytes*/Chondrocytes*/metabolism ; Chondrocytes*/Chondrocytes*/Chondrocytes*/drug effects ; Fibroblast Growth Factors*/Fibroblast Growth Factors*/Fibroblast Growth Factors*/pharmacology

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 Jan 22; Vol. 23 (1), pp. 34. Date of Electronic Publication: 2025 Jan 22.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration.

• Authors : Zhao, Xiang¹ (AUTHOR); Lin, Jieming² (AUTHOR); Liu, Mingyang¹ (AUTHOR)

• Source: Journal of Nanobiotechnology. 10/26/2024, Vol. 22 Issue 1, p1-18. 18p.

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Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

• Authors : Tian Jin; Di Wu; Xiao-Ming Liu

Subjects: Celastrol; Hollow mesoporous silica nanoparticle; Osteoarthritis

• Source: Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-15 (2020)

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Cartilage progenitor cells derived extracellular vesicles-based cell-free strategy for osteoarthritis treatment by efficient inflammation inhibition and extracellular matrix homeostasis restoration.

• Authors : Feng K; Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.; Wang F

Subjects: Extracellular Vesicles*/Extracellular Vesicles*/Extracellular Vesicles*/metabolism ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/therapy ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/metabolism

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Jun 19; Vol. 22 (1), pp. 345. Date of Electronic Publication: 2024 Jun 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity.

• Authors : Ding Z; Guizhou Medical University, Guiyang, 550004, Guizhou, China.; Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, China.

Subjects: Cartilage, Articular* ; Mesenchymal Stem Cells* ; Extracellular Vesicles*

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Feb 23; Vol. 22 (1), pp. 74. Date of Electronic Publication: 2024 Feb 23.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Articular chondrocyte-derived extracellular vesicles promote cartilage differentiation of human umbilical cord mesenchymal stem cells by activation of autophagy

• Authors : Ke Ma; Bo Zhu; Zetao Wang

Subjects: Autophagy; Chondrocytes; Chondrogenesis

• Source: Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-18 (2020)

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Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis.

• Authors : Wu, Jiangyi¹ (AUTHOR); Wu, Jinhui² (AUTHOR); Xiang, Wei³ (AUTHOR)

• Source: Journal of Nanobiotechnology. 9/11/2024, Vol. 22 Issue 1, p1-18. 18p.

تفاصيل العنوان

Hierarchical functional nanoparticles boost osteoarthritis therapy by utilizing joint-resident mesenchymal stem cells.

• Authors : Lu, Yao^1,2 (AUTHOR) ; Chen, Jieli¹ (AUTHOR); Li, Lihua³ (AUTHOR)

• Source: Journal of Nanobiotechnology. 2/19/2022, Vol. 20 Issue 1, p1-12. 12p.

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