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Publication : international journal of molecular sciences

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Academic Journal

Double Strike in Chronic Lymphocytic Leukemia—The Combination of BTK and BCL2 Inhibitors in Actual and Future Clinical Practice.

Authors : Zygmunciak, Przemyslaw¹ (AUTHOR); Dancewicz, Hanna^1,2 (AUTHOR); Stróżna, Katarzyna^1,3 (AUTHOR)

Subjects: *BRUTON tyrosine kinase; *CHRONIC lymphocytic leukemia; *PROTEIN-tyrosine kinase inhibitors

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3193. 22p.

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Academic Journal

Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights.

Authors : Anaya, Yamile Abuchard^1,2,3,4 (AUTHOR); Bracho, Ricardo Pequeno^1,2,3,4 (AUTHOR); Chauhan, Subhash C.^3,4 (AUTHOR)

Subjects: *NON-small-cell lung carcinoma; *SMALL molecules; *COMBINATION drug therapy

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2676. 15p.

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Academic Journal

Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2− Breast Cancer.

Authors : Ferrari, Paola¹ (AUTHOR) ; Schiavone, Maria Luisa² (AUTHOR); Scatena, Cristian^1,2 (AUTHOR)

Subjects: *SELECTIVE estrogen receptor modulators; *HORMONE therapy; *CYCLIN-dependent kinase inhibitors

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p3438. 37p.

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Academic Journal

Proteasome Inhibitors: Potential in Rheumatoid Arthritis Therapy?

Authors : Tarjányi, Oktávia¹ (AUTHOR); Olasz, Katalin² (AUTHOR); Rátky, Fanni¹ (AUTHOR)

Subjects: *PROTEASOME inhibitors; *RHEUMATOID arthritis; *AUTOIMMUNE diseases

Source: International Journal of Molecular Sciences. Apr2025, Vol. 26 Issue 7, p2943. 22p.

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Academic Journal

State of the Art of Immune Checkpoint Inhibitors in Unresectable Pancreatic Cancer: A Comprehensive Systematic Review.

Authors : Orlandi, Elena¹ (AUTHOR) ; Guasconi, Massimo^2,3 (AUTHOR); Romboli, Andrea^3,4 (AUTHOR)

Subjects: *CLINICAL trials; *IMMUNE checkpoint inhibitors; *ADVERSE health care events

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2620. 21p.

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Academic Journal

Drug Resistance in Late-Stage Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Patients After First-Line Treatment with Tyrosine Kinase Inhibitors.

Authors : Lee, Ching-Yi^1,2,3 (AUTHOR); Lee, Shih-Wei^1,2,3 (AUTHOR); Hsu, Yi-Chiung^2,3,4,5 (AUTHOR)

Subjects: *EPIDERMAL growth factor receptors; *NON-small-cell lung carcinoma; *PROTEIN-tyrosine kinase inhibitors

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p2042. 25p.

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Academic Journal

Rational Design and Optimization of Novel PDE5 Inhibitors for Targeted Colorectal Cancer Therapy: An In Silico Approach.

Authors : Oladeji, Samson Marvellous¹ (AUTHOR); Conteh, Deborah Ngozi² (AUTHOR); Bello, Lukman Abidemi^1,3 (AUTHOR)

Subjects: *CYCLIC guanylic acid; *PHOSPHODIESTERASE-5 inhibitors; *PHOSPHODIESTERASE inhibitors

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 5, p1937. 16p.

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Academic Journal

Models of Early Resistance to CDK4/6 Inhibitors Unveil Potential Therapeutic Treatment Sequencing.

Authors : Zapatero-Solana, Elisabet¹ (AUTHOR); Ding, Yan² (AUTHOR); Pulliam, Nicholas^1,2 (AUTHOR)

Subjects: *CYCLIN-dependent kinase inhibitors; *FULVESTRANT; *BREAST cancer

Source: International Journal of Molecular Sciences. Mar2025, Vol. 26 Issue 6, p2643. 18p.

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Academic Journal

Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism.

Authors : Buneeva, Olga¹ (AUTHOR) ; Medvedev, Alexei¹ (AUTHOR)

Subjects: *MONOAMINE oxidase inhibitors; *PARKINSON'S disease; *MONOAMINE oxidase

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1248. 25p.

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Academic Journal

Analysis of Protein Inhibitors of Trypsin in Quinoa, Amaranth and Lupine Seeds. Selection and Deep Structure–Function Characterization of the Amaranthus caudatus Species.

Authors : Hernández de la Torre, Martha¹ (AUTHOR) ; Covaleda-Cortés, Giovanni² (AUTHOR) ; Montesinos, Laura³ (AUTHOR)

Subjects: *PHYTOPATHOGENIC microorganisms; *HEAT stability in proteins; *TRYPSIN inhibitors

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1150. 25p.

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فلترة النتائج

Double Strike in Chronic Lymphocytic Leukemia—The Combination of BTK and BCL2 Inhibitors in Actual and Future Clinical Practice.

Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights.

Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2− Breast Cancer.

Proteasome Inhibitors: Potential in Rheumatoid Arthritis Therapy?

State of the Art of Immune Checkpoint Inhibitors in Unresectable Pancreatic Cancer: A Comprehensive Systematic Review.

Drug Resistance in Late-Stage Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Patients After First-Line Treatment with Tyrosine Kinase Inhibitors.

Rational Design and Optimization of Novel PDE5 Inhibitors for Targeted Colorectal Cancer Therapy: An In Silico Approach.

Models of Early Resistance to CDK4/6 Inhibitors Unveil Potential Therapeutic Treatment Sequencing.

Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism.

Analysis of Protein Inhibitors of Trypsin in Quinoa, Amaranth and Lupine Seeds. Selection and Deep Structure–Function Characterization of the Amaranthus caudatus Species.

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